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• W2013977400 abstract "The term innate immunity refers to a number of evolutionary ancient mechanisms that serve to defend animals and plants against infection. Genetically tractable model organisms, especially Drosophila, have contributed greatly to advances in our understanding of mammalian innate immunity [1Khush R.S. Lemaitre B. Genes that fight infection what the Drosophila genome says about animal immunity.Trends Genet. 2000; 16: 442-449Abstract Full Text Full Text PDF PubMed Scopus (126) Google Scholar, 2Hoffmann J.A. Reichhart J.M. Drosophila innate immunity an evolutionary perspective.Nat. Immunol. 2002; 3: 121-126Crossref PubMed Scopus (825) Google Scholar]. Essentially, nothing is known about immune responses in the nematode Caenorhabditis elegans[3Aballay A. Ausubel F.M. Caenorhabditis elegans as a host for the study of host-pathogen interactions.Curr. Opin. Microbiol. 2002; 5: 97-101Crossref PubMed Scopus (125) Google Scholar, 4Ewbank J.J. Tackling both sides of the host-pathogen equation with Caenorhabditis elegans.Microbes Infect. 2002; 4: 247-256Crossref PubMed Scopus (89) Google Scholar]. Using high-density cDNA microarrays, we show here that infection of C. elegans by the Gram-negative bacterium Serratia marcescens provokes a marked upregulation of the expression of many genes. Among the most robustly induced are genes encoding lectins and lysozymes, known to be involved in immune responses in other organisms. Certain infection-inducible genes are under the control of the DBL-1/TGFβ pathway [5Mochii M. Yoshida S. Morita K. Kohara Y. Ueno N. Identification of transforming growth factor-beta- regulated genes in Caenorhabditis elegans by differential hybridization of arrayed cDNAs.Proc. Natl. Acad. Sci. USA. 1999; 96: 15020-15025Crossref PubMed Scopus (81) Google Scholar]. We found that dbl-1 mutants exhibit increased susceptibility to infection. Conversely, overexpression of the lysozyme gene lys-1 augments the resistance of C. elegans to S. marcescens. These results constitute the first demonstration of inducible antibacterial defenses in C. elegans and open new avenues for the investigation of evolutionary conserved mechanisms of innate immunity." @default.
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• W2013977400 date "2002-07-01" @default.
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• W2013977400 title "Inducible Antibacterial Defense System in C. elegans" @default.
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• W2013977400 doi "https://doi.org/10.1016/s0960-9822(02)00928-4" @default.
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