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• W2013977528 abstract "Abstract Many of the healthcare consequences of cigarette smoking could be due to its ability to compromise the immune system, and in respiratory diseases like chronic obstructive pulmonary disease (COPD), a constant low level of infection could be responsible for some of the symptoms/pathology. The aim was to assess the impact of cigarette smoke (CS) on the release of innate effector cytokines in THP‐1 cells and human lung macrophages, and to determine the molecular mechanism behind the altered response. Cells were exposed to CS with and without endotoxin stimulus, cytokines, glutathione, mitogen‐activated protein kinase (MAPK) phosphorylation, IκB kinase‐2 (IKK‐2) activity, nuclear factor kappa B (NF‐κB), and activator protein‐1 (AP‐1) pathway activation was measured. Attempts were made to mimic or block the effect of CS by using nicotine, nitric oxide donors/inhibitors, prostanoid inhibitors, and anti‐oxidants. Results showed that CS initially delayed the production of “innate” cytokines (e.g., IL‐1β and IL‐6) and reduced glutathione levels. This was associated with a reduction in NF‐κB pathway activation, which suggested a causative link. CS also increased the phosphorylation of MAPK's and the production of IL‐8 but interestingly only in stimulated cells. Exogenous glutathione treatment reversed both these effects of CS, which suggests that this molecule may play a central role. In conclusion, this data provides a novel mechanistic explanation for why smokers have increased prevalence/severity of respiratory infections. In addition, the suppression of the innate response is accompanied by an increase in the neutrophil chemoattractant, IL‐8, which may suggest a link to the pathogenesis of smoking‐related inflammatory disease. J. Cell. Physiol. 214:27–37, 2008. © 2007 Wiley‐Liss, Inc." @default.
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• W2013977528 date "2007-05-31" @default.
• W2013977528 modified "2023-10-13" @default.
• W2013977528 title "Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages" @default.
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• W2013977528 doi "https://doi.org/10.1002/jcp.21158" @default.
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