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• W2013979092 abstract "The role of ascending noradrenaline (NA) containing neuronal systems in sleep and waking mechanisms in the rat was investigated by making selective lesions of these systems with the neurotoxic compound 6-hydroxydopamine (6-OH-DA). The 6-OH-DA (1–16 μg) was injected intracerebrally close to the ascending NA axons in the mesencephalon. After the injection the EEG and EMG were continuously recorded for 4–8 days and the time the animal spent in waking and in different sleep states was measured. Determination of endogenous NA in the forebrain, histochemical analysis of NA varicosities in the cerebral cortex and measurement of uptake-retention of [3H]NA in slices from the cerebral cortex were performed 25–40 days after the injection to evaluate the lesion of the NA axons produced by 6-OH-DA. The 6-OH-DA induced lesion of catecholamine (CA) axons was reflected by acute retrograde accumulations of CA in the axons and long-term anterograde degeneration of nerve terminals as revealed by disappearance of uptake and storage of NA. Two days after surgery, a dose dependent unspecific damage of brain tissue was observed at the site of 6-OH-DA injection. The unspecific changes were much less pronounced 25–40 days after the injection than after 2 days. The degree of damage to the NA neurons, however, was largely independent of the amount given indicating a selective action of 6-OH-DA on NA axons. EEG waking as characterized by low voltage fast activity (desynchronized activity) was markedly suppressed acutely following a lesion of the ascending dorsal CA bundle. Instead the recordings exhibited a corresponding increase in periods dominated by high voltage slow waves and more synchronized activity. In spite of these changes, behavioral wakefulness seemed unaffected by the lesion. There was no difference from saline injected controls in the time spent in slow wave sleep as characterized by continuous high voltage slow waves and behavioral sleep, whereas a small decrease in paradoxical sleep was seen. The decrease in EEG waking was most pronounced during the first 4 days after the lesion. Thereafter a gradual recovery of waking activity started and recordings made 1 month later showed that the animals had regained a normal amount of EEG waking. The acute EEG changes observed were independent of the amount of 6-OH-DA injected. Injection at different sites also did not seem to influence the results. There was, however, a good correlation between the time of EEG waking and the degree of lesion of the dorsal CA bundle. The findings suggest that the NA neurons of the locus coeruleus projecting via the dorsal CA bundle to certain forebrain areas,e.g., the cerebral cortex, are important for maintenance of the electrocortical aspects of waking." @default.
• W2013979092 created "2016-06-24" @default.
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• W2013979092 date "1974-07-01" @default.
• W2013979092 modified "2023-10-11" @default.
• W2013979092 title "The effect of lesions of ascending noradrenaline pathways on sleep and waking in the rat" @default.
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• W2013979092 doi "https://doi.org/10.1016/0006-8993(74)90109-7" @default.
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