FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013985547> ?p ?o ?g. }

• W2013985547 endingPage "E77" @default.
• W2013985547 startingPage "E68" @default.
• W2013985547 abstract "The purpose of this research was to explore the utility of beta cyclodextrin (betaCD) and beta cyclodextrin derivatives (hydroxypropyl-beta-cyclodextrin [HPbetaCD], sulfobutylether-beta-CD [SBbetaCD], and a randomly methylated-beta-CD [RMbetaCD]) to form inclusion complexes with the antitumoral drug, beta-lapachone (betaLAP), in order to overcome the problem of its poor water solubility. RMbetaCD presented the highest efficiency for betaLAP solubilization and was selected to develop solid-state binary systems. Differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), Fourier transform infrared (FTIR) and optical and scanning electron microscopy results suggest the formation of inclusion complexes by both freeze-drying and kneading techniques with a dramatic improvement in drug dissolution efficiency at 20-minute dissolution efficiency (DE(20-minute) 67.15% and 88.22%, respectively) against the drug (DE(20-minute) 27.11%) or the betaCD/drug physical mixture (DE(20-minute) 27.22%). However, the kneading method gives a highly crystalline material that together with the adequate drug dissolution profile make it the best procedure in obtaining inclusion complexes of RMbetaCD/betaLAP convenient for different applications of betaLAP." @default.
• W2013985547 created "2016-06-24" @default.
• W2013985547 creator A5011459414 @default.
• W2013985547 creator A5020730115 @default.
• W2013985547 creator A5037883413 @default.
• W2013985547 creator A5051273476 @default.
• W2013985547 creator A5060838517 @default.
• W2013985547 date "2007-09-01" @default.
• W2013985547 modified "2023-10-18" @default.
• W2013985547 title "Characterization of β-lapachone and methylated β-cyclodextrin solid-state systems" @default.
• W2013985547 cites W1970511552 @default.
• W2013985547 cites W1980459622 @default.
• W2013985547 cites W2008407022 @default.
• W2013985547 cites W2020337784 @default.
• W2013985547 cites W2021409079 @default.
• W2013985547 cites W2028973432 @default.
• W2013985547 cites W2035546193 @default.
• W2013985547 cites W2044609602 @default.
• W2013985547 cites W2046017608 @default.
• W2013985547 cites W2049119654 @default.
• W2013985547 cites W2054253259 @default.
• W2013985547 cites W2065938260 @default.
• W2013985547 cites W2078708719 @default.
• W2013985547 cites W2084244624 @default.
• W2013985547 cites W2091226683 @default.
• W2013985547 cites W2093348832 @default.
• W2013985547 cites W2106729829 @default.
• W2013985547 cites W2110983380 @default.
• W2013985547 cites W2119922091 @default.
• W2013985547 cites W2122723798 @default.
• W2013985547 cites W2129915287 @default.
• W2013985547 cites W2147720569 @default.
• W2013985547 cites W2162163992 @default.
• W2013985547 cites W2167108516 @default.
• W2013985547 cites W2323692772 @default.
• W2013985547 cites W391268505 @default.
• W2013985547 cites W4244683536 @default.
• W2013985547 doi "https://doi.org/10.1208/pt0803060" @default.
• W2013985547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2750556" @default.
• W2013985547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17915810" @default.
• W2013985547 hasPublicationYear "2007" @default.
• W2013985547 type Work @default.
• W2013985547 sameAs 2013985547 @default.
• W2013985547 citedByCount "42" @default.
• W2013985547 countsByYear W20139855472012 @default.
• W2013985547 countsByYear W20139855472013 @default.
• W2013985547 countsByYear W20139855472015 @default.
• W2013985547 countsByYear W20139855472016 @default.
• W2013985547 countsByYear W20139855472017 @default.
• W2013985547 countsByYear W20139855472018 @default.
• W2013985547 countsByYear W20139855472019 @default.
• W2013985547 countsByYear W20139855472020 @default.
• W2013985547 countsByYear W20139855472021 @default.
• W2013985547 countsByYear W20139855472023 @default.
• W2013985547 crossrefType "journal-article" @default.
• W2013985547 hasAuthorship W2013985547A5011459414 @default.
• W2013985547 hasAuthorship W2013985547A5020730115 @default.
• W2013985547 hasAuthorship W2013985547A5037883413 @default.
• W2013985547 hasAuthorship W2013985547A5051273476 @default.
• W2013985547 hasAuthorship W2013985547A5060838517 @default.
• W2013985547 hasBestOaLocation W20139855472 @default.
• W2013985547 hasConcept C121332964 @default.
• W2013985547 hasConcept C127413603 @default.
• W2013985547 hasConcept C13965031 @default.
• W2013985547 hasConcept C14029885 @default.
• W2013985547 hasConcept C155574463 @default.
• W2013985547 hasConcept C159985019 @default.
• W2013985547 hasConcept C160892712 @default.
• W2013985547 hasConcept C178790620 @default.
• W2013985547 hasConcept C185039092 @default.
• W2013985547 hasConcept C185592680 @default.
• W2013985547 hasConcept C192562407 @default.
• W2013985547 hasConcept C202270520 @default.
• W2013985547 hasConcept C26771246 @default.
• W2013985547 hasConcept C2778649806 @default.
• W2013985547 hasConcept C2779433975 @default.
• W2013985547 hasConcept C2781430271 @default.
• W2013985547 hasConcept C2910962261 @default.
• W2013985547 hasConcept C39519442 @default.
• W2013985547 hasConcept C42360764 @default.
• W2013985547 hasConcept C43617362 @default.
• W2013985547 hasConcept C8010536 @default.
• W2013985547 hasConcept C88380143 @default.
• W2013985547 hasConcept C97355855 @default.
• W2013985547 hasConceptScore W2013985547C121332964 @default.
• W2013985547 hasConceptScore W2013985547C127413603 @default.
• W2013985547 hasConceptScore W2013985547C13965031 @default.
• W2013985547 hasConceptScore W2013985547C14029885 @default.
• W2013985547 hasConceptScore W2013985547C155574463 @default.
• W2013985547 hasConceptScore W2013985547C159985019 @default.
• W2013985547 hasConceptScore W2013985547C160892712 @default.
• W2013985547 hasConceptScore W2013985547C178790620 @default.
• W2013985547 hasConceptScore W2013985547C185039092 @default.
• W2013985547 hasConceptScore W2013985547C185592680 @default.
• W2013985547 hasConceptScore W2013985547C192562407 @default.
• W2013985547 hasConceptScore W2013985547C202270520 @default.
• W2013985547 hasConceptScore W2013985547C26771246 @default.
• W2013985547 hasConceptScore W2013985547C2778649806 @default.

• next