FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013986885> ?p ?o ?g. }

• W2013986885 endingPage "8" @default.
• W2013986885 startingPage "382" @default.
• W2013986885 abstract "The alkylating carcinogen 1,2-dimethylhydrazine (DMH) induces colonic tumors with high incidence. The sites of in vivo modification of target macromolecules were studied using [methyl-3H]DMH. Carcinogen binding to subcellular fractions of colonic epithelial cells was analyzed at time intervals ranging from 10 min to 36 hr, with particular emphasis on the alkylation of nuclear constituents. DMH modifies not only nucleic acids but also histones and other DNA-binding proteins in the target cells. Separation of the 3H-methylated amino acids showed aberrant methylation patterns after exposure to [3H]DMH, as compared with methylations observed with [methyl-3H]methionine as a natural methyl group donor. DMH-modified histone H1 contained methylated lysin, arginine, and histidine residues not normally found, and other histones had abnormal methylarginine contents. High-mobility-group proteins and other nuclear proteins contained methyllysine residues not normally detected. Proteins known to be associated with template-active and more accessible DNA sequences, such as the high-mobility group proteins and the multiacetylated forms of histones H3 and H4, were preferentially damaged after exposure to [3H]DmH. The result suggests that carcinogen-induced chromosomal damage is not random and may selectively affect proteins in the actively transcribing or replicating genes in the target cells. That damage affects the amino acids most likely to be involved in DNA binding." @default.
• W2013986885 created "2016-06-24" @default.
• W2013986885 creator A5016971151 @default.
• W2013986885 creator A5047359621 @default.
• W2013986885 creator A5052619778 @default.
• W2013986885 date "1982-02-01" @default.
• W2013986885 modified "2023-09-23" @default.
• W2013986885 title "Aberrant and nonrandom methylation of chromosomal DNA-binding proteins of colonic epithelial cells by 1,2-dimethylhydrazine." @default.
• W2013986885 cites W1488005560 @default.
• W2013986885 cites W1519312658 @default.
• W2013986885 cites W1545816668 @default.
• W2013986885 cites W1553926216 @default.
• W2013986885 cites W1775749144 @default.
• W2013986885 cites W1963905449 @default.
• W2013986885 cites W1976943666 @default.
• W2013986885 cites W1979009173 @default.
• W2013986885 cites W1982419990 @default.
• W2013986885 cites W1988794233 @default.
• W2013986885 cites W1998886326 @default.
• W2013986885 cites W1999708196 @default.
• W2013986885 cites W2003396737 @default.
• W2013986885 cites W2014974226 @default.
• W2013986885 cites W2015645158 @default.
• W2013986885 cites W2017470279 @default.
• W2013986885 cites W2029475485 @default.
• W2013986885 cites W2031363723 @default.
• W2013986885 cites W2035906127 @default.
• W2013986885 cites W2035973152 @default.
• W2013986885 cites W2036027789 @default.
• W2013986885 cites W2042723858 @default.
• W2013986885 cites W2055199440 @default.
• W2013986885 cites W2064414056 @default.
• W2013986885 cites W2065843330 @default.
• W2013986885 cites W2070526552 @default.
• W2013986885 cites W2075499212 @default.
• W2013986885 cites W2083085787 @default.
• W2013986885 cites W2087180815 @default.
• W2013986885 cites W2100837269 @default.
• W2013986885 cites W2160710868 @default.
• W2013986885 cites W2163256113 @default.
• W2013986885 cites W2497816193 @default.
• W2013986885 cites W2042042288 @default.
• W2013986885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6895714" @default.
• W2013986885 hasPublicationYear "1982" @default.
• W2013986885 type Work @default.
• W2013986885 sameAs 2013986885 @default.
• W2013986885 citedByCount "7" @default.
• W2013986885 countsByYear W20139868852015 @default.
• W2013986885 crossrefType "journal-article" @default.
• W2013986885 hasAuthorship W2013986885A5016971151 @default.
• W2013986885 hasAuthorship W2013986885A5047359621 @default.
• W2013986885 hasAuthorship W2013986885A5052619778 @default.
• W2013986885 hasConcept C104317684 @default.
• W2013986885 hasConcept C114246631 @default.
• W2013986885 hasConcept C121608353 @default.
• W2013986885 hasConcept C153911025 @default.
• W2013986885 hasConcept C185592680 @default.
• W2013986885 hasConcept C24107716 @default.
• W2013986885 hasConcept C2777745080 @default.
• W2013986885 hasConcept C2778452354 @default.
• W2013986885 hasConcept C2778460671 @default.
• W2013986885 hasConcept C2779932572 @default.
• W2013986885 hasConcept C2780912031 @default.
• W2013986885 hasConcept C33288867 @default.
• W2013986885 hasConcept C515207424 @default.
• W2013986885 hasConcept C526805850 @default.
• W2013986885 hasConcept C54355233 @default.
• W2013986885 hasConcept C552990157 @default.
• W2013986885 hasConcept C55493867 @default.
• W2013986885 hasConcept C555283112 @default.
• W2013986885 hasConcept C64927066 @default.
• W2013986885 hasConcept C86339819 @default.
• W2013986885 hasConcept C86803240 @default.
• W2013986885 hasConcept C87026931 @default.
• W2013986885 hasConcept C94966510 @default.
• W2013986885 hasConceptScore W2013986885C104317684 @default.
• W2013986885 hasConceptScore W2013986885C114246631 @default.
• W2013986885 hasConceptScore W2013986885C121608353 @default.
• W2013986885 hasConceptScore W2013986885C153911025 @default.
• W2013986885 hasConceptScore W2013986885C185592680 @default.
• W2013986885 hasConceptScore W2013986885C24107716 @default.
• W2013986885 hasConceptScore W2013986885C2777745080 @default.
• W2013986885 hasConceptScore W2013986885C2778452354 @default.
• W2013986885 hasConceptScore W2013986885C2778460671 @default.
• W2013986885 hasConceptScore W2013986885C2779932572 @default.
• W2013986885 hasConceptScore W2013986885C2780912031 @default.
• W2013986885 hasConceptScore W2013986885C33288867 @default.
• W2013986885 hasConceptScore W2013986885C515207424 @default.
• W2013986885 hasConceptScore W2013986885C526805850 @default.
• W2013986885 hasConceptScore W2013986885C54355233 @default.
• W2013986885 hasConceptScore W2013986885C552990157 @default.
• W2013986885 hasConceptScore W2013986885C55493867 @default.
• W2013986885 hasConceptScore W2013986885C555283112 @default.
• W2013986885 hasConceptScore W2013986885C64927066 @default.
• W2013986885 hasConceptScore W2013986885C86339819 @default.
• W2013986885 hasConceptScore W2013986885C86803240 @default.
• W2013986885 hasConceptScore W2013986885C87026931 @default.
• W2013986885 hasConceptScore W2013986885C94966510 @default.

• next