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- W2013986910 abstract "Abstract PS1, a complex polysaccharide derived from Mycobacterium bovis (Bacillus Calmette-Guérin, BCG) with considerable antitumour activity in-vivo, was loaded onto gelatin microparticles (mean diam. 1·45 μm) at a level shown to not produce the burst effect often seen with drug-loaded micro-particulate systems. In-vitro dissolution experiments had demonstrated a sustained-release behaviour, with a half-life of approximately 8 h for what is an extremely water-soluble material. These PS1/gelatin systems had no measurable cytotoxicity against an S180 murine sarcoma cell in-vitro although fibronectin-mediated targeting of the microparticles for the tumour cells could be demonstrated. Injection into mice, with the S180 cells, of PS1 solutions or suspensions of PS1-loaded gelatin microparticles resulted in almost identical dose-related suppression for the tumour cell growth. When injected at intervals following injection of the tumour cells, however, for a period of 24–48 h there was a relatively enhanced activity of the formulated PS1, compared with the aqueous solution, after which both formulated and unformulated material became progressively less effective." @default.
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- W2013986910 date "1994-11-01" @default.
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- W2013986910 title "In-vivo and In-vitro Targeting of a Murine Sarcoma by Gelatin Microparticles Loaded with a Glycan (PS1)" @default.
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- W2013986910 doi "https://doi.org/10.1111/j.2042-7158.1994.tb05703.x" @default.
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