Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013986963> ?p ?o ?g. }
- W2013986963 endingPage "512" @default.
- W2013986963 startingPage "503" @default.
- W2013986963 abstract "The glypican family of heparan sulfate proteoglycans has been implicated in formation of morphogen gradients. Here, we examine the role of the glypican Dally-like protein (Dlp) in shaping the Wingless gradient in the Drosophila wing disc. Surprisingly, we find that Dlp has opposite effects at high and low levels of Wingless. Dlp promotes low-level Wingless activity but reduces high-level Wingless activity. We present evidence that the Wg antagonist Notum acts to induce cleavage of the Dlp glypican at the level of its GPI anchor, which leads to shedding of Dlp. Thus, spatially regulated modification of Dlp by Notum employs the ligand binding activity of Dlp to promote or inhibit signaling in a context-dependent manner. Notum-induced shedding of Dlp could convert Dlp from a membrane-tethered coreceptor to a secreted antagonist." @default.
- W2013986963 created "2016-06-24" @default.
- W2013986963 creator A5003103449 @default.
- W2013986963 creator A5023334163 @default.
- W2013986963 creator A5067307589 @default.
- W2013986963 creator A5081151182 @default.
- W2013986963 date "2004-10-01" @default.
- W2013986963 modified "2023-10-16" @default.
- W2013986963 title "Opposing Activities of Dally-like Glypican at High and Low Levels of Wingless Morphogen Activity" @default.
- W2013986963 cites W1566448969 @default.
- W2013986963 cites W1648692159 @default.
- W2013986963 cites W1649982107 @default.
- W2013986963 cites W1949772429 @default.
- W2013986963 cites W1971540677 @default.
- W2013986963 cites W1975510007 @default.
- W2013986963 cites W1977203585 @default.
- W2013986963 cites W1978974209 @default.
- W2013986963 cites W1989117766 @default.
- W2013986963 cites W2000800531 @default.
- W2013986963 cites W2007230427 @default.
- W2013986963 cites W2015279698 @default.
- W2013986963 cites W2017156935 @default.
- W2013986963 cites W2029307548 @default.
- W2013986963 cites W2029781891 @default.
- W2013986963 cites W2035765497 @default.
- W2013986963 cites W2037921918 @default.
- W2013986963 cites W2046970439 @default.
- W2013986963 cites W2047745952 @default.
- W2013986963 cites W2049741730 @default.
- W2013986963 cites W2053698830 @default.
- W2013986963 cites W2056621404 @default.
- W2013986963 cites W2061364925 @default.
- W2013986963 cites W2061419466 @default.
- W2013986963 cites W2062713760 @default.
- W2013986963 cites W2078402042 @default.
- W2013986963 cites W2082147644 @default.
- W2013986963 cites W2083432523 @default.
- W2013986963 cites W2083571731 @default.
- W2013986963 cites W2085204257 @default.
- W2013986963 cites W2087336633 @default.
- W2013986963 cites W2092728011 @default.
- W2013986963 cites W2093957890 @default.
- W2013986963 cites W2095465363 @default.
- W2013986963 cites W2098357545 @default.
- W2013986963 cites W2099975379 @default.
- W2013986963 cites W2100585860 @default.
- W2013986963 cites W2108184622 @default.
- W2013986963 cites W2108345995 @default.
- W2013986963 cites W2112499390 @default.
- W2013986963 cites W2113780941 @default.
- W2013986963 cites W2122965729 @default.
- W2013986963 cites W2124955351 @default.
- W2013986963 cites W2139936955 @default.
- W2013986963 cites W2141906259 @default.
- W2013986963 cites W2142112187 @default.
- W2013986963 cites W2143366342 @default.
- W2013986963 cites W2148158930 @default.
- W2013986963 cites W2152649594 @default.
- W2013986963 cites W2157194244 @default.
- W2013986963 cites W2158626657 @default.
- W2013986963 cites W2160014040 @default.
- W2013986963 cites W2161481085 @default.
- W2013986963 cites W2168149321 @default.
- W2013986963 cites W2169483492 @default.
- W2013986963 cites W2176777897 @default.
- W2013986963 cites W2422481370 @default.
- W2013986963 cites W4211075026 @default.
- W2013986963 cites W4238813159 @default.
- W2013986963 cites W46783220 @default.
- W2013986963 doi "https://doi.org/10.1016/j.devcel.2004.08.005" @default.
- W2013986963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15469839" @default.
- W2013986963 hasPublicationYear "2004" @default.
- W2013986963 type Work @default.
- W2013986963 sameAs 2013986963 @default.
- W2013986963 citedByCount "198" @default.
- W2013986963 countsByYear W20139869632012 @default.
- W2013986963 countsByYear W20139869632013 @default.
- W2013986963 countsByYear W20139869632014 @default.
- W2013986963 countsByYear W20139869632015 @default.
- W2013986963 countsByYear W20139869632016 @default.
- W2013986963 countsByYear W20139869632017 @default.
- W2013986963 countsByYear W20139869632018 @default.
- W2013986963 countsByYear W20139869632019 @default.
- W2013986963 countsByYear W20139869632020 @default.
- W2013986963 countsByYear W20139869632021 @default.
- W2013986963 countsByYear W20139869632022 @default.
- W2013986963 countsByYear W20139869632023 @default.
- W2013986963 crossrefType "journal-article" @default.
- W2013986963 hasAuthorship W2013986963A5003103449 @default.
- W2013986963 hasAuthorship W2013986963A5023334163 @default.
- W2013986963 hasAuthorship W2013986963A5067307589 @default.
- W2013986963 hasAuthorship W2013986963A5081151182 @default.
- W2013986963 hasBestOaLocation W20139869631 @default.
- W2013986963 hasConcept C104317684 @default.
- W2013986963 hasConcept C151730666 @default.
- W2013986963 hasConcept C2778386714 @default.
- W2013986963 hasConcept C2779343474 @default.
- W2013986963 hasConcept C54355233 @default.