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• W2013993149 abstract "Nogo-A is part of the reticulon family of proteins localized to the myelin and oligodendroglial plasma membranes. Nogo-A specifically initiates signal transduction cascades limiting axonal regrowth following injury and disease in the adult mammalian central nervous system (CNS). Recent novel data support the contention that neuronal Nogo-A plays an important role in regulating cytoskeletal re-organization without the requirement of signaling through its cognate receptor (Nogo receptor). These data, along with the recent findings that the N-terminus of Nogo-A can interact with integrins and that NgR1 interacts with the amyloid precursor protein extracellularly, as well as novel findings showing ubiquitin ligases binding with Nogo-A intracellularly add a layer of complexity to its functional role in the CNS." @default.
• W2013993149 created "2016-06-24" @default.
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• W2013993149 date "2010-07-01" @default.
• W2013993149 modified "2023-09-27" @default.
• W2013993149 title "Molecular regulation of Nogo-A in neural cells: Novel insights into structure and function" @default.
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• W2013993149 doi "https://doi.org/10.1016/j.biocel.2010.02.007" @default.
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