FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014001027> ?p ?o ?g. }

• W2014001027 endingPage "952" @default.
• W2014001027 startingPage "946" @default.
• W2014001027 abstract "Abstract The plasminogen/plasmin proteolytic cascade plays an important role in extracellular matrix remodeling. The presence of the two plasminogen activators (PAs), tissue‐type plasminogen activator (tPA), and urokinase‐type plasminogen activator (uPA), and their inhibitor type 1 (PAI‐1) in bone cells, suggests a role in one or more aspects of bone resorption such as osteoclast formation, mineral dissolution, and degradation of the organic matrix. These different processes were assayed in vitro using cells derived from mice with either tPA (tPA−/−), uPA (uPA−/−), PAI‐1 (PAI‐1−/−) inactivation or with a combined inactivation (tPA−/−:uPA−/−) and compared with wild‐type mice (WT). First, osteoclast formation, assessed by investigating the number and characteristics of tartrate‐resistant acid phosphatase–positive multinucleated cells formed in cocultures of primary osteoblasts and bone marrow cells treated with 1α,25‐dihydroxyvitamin D 3 , was not different between the different cell types. Second, dentine resorption, an assay for osteoclast activity, was not affected by the combined deficiency of both tPA and uPA. Finally, the ability to degrade nonmineralized bone‐like matrix was however, significantly reduced in tPA−/−:uPA−/− cells compared with WT cells (28.1 ± 0.6%, n = 6 vs. 56.4 ± 3.1%, n = 6, respectively, p < 0.0001). Surprisingly, collagen proteolysis by bone cells was not dependent on the presence of plasmin as suggested by degradation assays performed on type I 3 H‐collagen films. Taken together, these data suggest that the plasminogen activator/plasmin system is not required for osteoclast formation, nor for the resorption of the mineral phase, but is involved in the removal of noncollagenous proteins present in the nonmineralized bone matrix." @default.
• W2014001027 created "2016-06-24" @default.
• W2014001027 creator A5003437398 @default.
• W2014001027 creator A5034320377 @default.
• W2014001027 creator A5069853428 @default.
• W2014001027 creator A5077350979 @default.
• W2014001027 creator A5087589975 @default.
• W2014001027 date "1999-06-01" @default.
• W2014001027 modified "2023-10-11" @default.
• W2014001027 title "The Role of the Plasminogen System in Bone Resorption In Vitro" @default.
• W2014001027 cites W1482195692 @default.
• W2014001027 cites W1544269629 @default.
• W2014001027 cites W155136349 @default.
• W2014001027 cites W1772675489 @default.
• W2014001027 cites W1885242166 @default.
• W2014001027 cites W1924436749 @default.
• W2014001027 cites W1940380821 @default.
• W2014001027 cites W1949259756 @default.
• W2014001027 cites W1955836474 @default.
• W2014001027 cites W1970293798 @default.
• W2014001027 cites W1970603461 @default.
• W2014001027 cites W1972597519 @default.
• W2014001027 cites W1977553486 @default.
• W2014001027 cites W2001116495 @default.
• W2014001027 cites W2003275790 @default.
• W2014001027 cites W2016918804 @default.
• W2014001027 cites W2019528718 @default.
• W2014001027 cites W2019615996 @default.
• W2014001027 cites W2022087872 @default.
• W2014001027 cites W2030240788 @default.
• W2014001027 cites W2038213930 @default.
• W2014001027 cites W2044175751 @default.
• W2014001027 cites W2044669548 @default.
• W2014001027 cites W2046758804 @default.
• W2014001027 cites W2047131018 @default.
• W2014001027 cites W2048666989 @default.
• W2014001027 cites W2054358569 @default.
• W2014001027 cites W2055218044 @default.
• W2014001027 cites W2064543503 @default.
• W2014001027 cites W2069309983 @default.
• W2014001027 cites W2075700478 @default.
• W2014001027 cites W2085864430 @default.
• W2014001027 cites W2091273235 @default.
• W2014001027 cites W2091478316 @default.
• W2014001027 cites W2092191109 @default.
• W2014001027 cites W2094875212 @default.
• W2014001027 cites W2107908226 @default.
• W2014001027 cites W2112990955 @default.
• W2014001027 cites W2122112217 @default.
• W2014001027 cites W4230802353 @default.
• W2014001027 doi "https://doi.org/10.1359/jbmr.1999.14.6.946" @default.
• W2014001027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10352103" @default.
• W2014001027 hasPublicationYear "1999" @default.
• W2014001027 type Work @default.
• W2014001027 sameAs 2014001027 @default.
• W2014001027 citedByCount "82" @default.
• W2014001027 countsByYear W20140010272012 @default.
• W2014001027 countsByYear W20140010272013 @default.
• W2014001027 countsByYear W20140010272014 @default.
• W2014001027 countsByYear W20140010272015 @default.
• W2014001027 countsByYear W20140010272016 @default.
• W2014001027 countsByYear W20140010272017 @default.
• W2014001027 countsByYear W20140010272018 @default.
• W2014001027 countsByYear W20140010272019 @default.
• W2014001027 countsByYear W20140010272020 @default.
• W2014001027 countsByYear W20140010272021 @default.
• W2014001027 countsByYear W20140010272022 @default.
• W2014001027 countsByYear W20140010272023 @default.
• W2014001027 crossrefType "journal-article" @default.
• W2014001027 hasAuthorship W2014001027A5003437398 @default.
• W2014001027 hasAuthorship W2014001027A5034320377 @default.
• W2014001027 hasAuthorship W2014001027A5069853428 @default.
• W2014001027 hasAuthorship W2014001027A5077350979 @default.
• W2014001027 hasAuthorship W2014001027A5087589975 @default.
• W2014001027 hasConcept C101990758 @default.
• W2014001027 hasConcept C126322002 @default.
• W2014001027 hasConcept C134018914 @default.
• W2014001027 hasConcept C136403682 @default.
• W2014001027 hasConcept C146562846 @default.
• W2014001027 hasConcept C153911025 @default.
• W2014001027 hasConcept C181199279 @default.
• W2014001027 hasConcept C185592680 @default.
• W2014001027 hasConcept C202751555 @default.
• W2014001027 hasConcept C2776033226 @default.
• W2014001027 hasConcept C2776892390 @default.
• W2014001027 hasConcept C2779679481 @default.
• W2014001027 hasConcept C2781071845 @default.
• W2014001027 hasConcept C55493867 @default.
• W2014001027 hasConcept C673006 @default.
• W2014001027 hasConcept C71924100 @default.
• W2014001027 hasConcept C86803240 @default.
• W2014001027 hasConcept C95444343 @default.
• W2014001027 hasConceptScore W2014001027C101990758 @default.
• W2014001027 hasConceptScore W2014001027C126322002 @default.
• W2014001027 hasConceptScore W2014001027C134018914 @default.
• W2014001027 hasConceptScore W2014001027C136403682 @default.
• W2014001027 hasConceptScore W2014001027C146562846 @default.
• W2014001027 hasConceptScore W2014001027C153911025 @default.

• next