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- W2014003433 abstract "Abstract: This study aimed to evaluate the effects of exposure to manganese (Mn) and lead (Pb) on immunesystem. The subjects were 42 male workers, among whom 13 office workers (Group I) had never beenoccupationally exposed to heavy metals, 21 were worked in manufacturing factories (Group II) and 8 werewelders (Group III). The mean blood Mn and Pb level by groups were significantly different. The numbersof CD19+ and total lymphocytes in Group I were significantly higher than those in other groups, but nosignificant differences were found in other T lymphocytes subpopulation. Mn and Pb concentrations showednegative correlation with T lymphocytes subpopulation, but Mn concentrations were statistical significances withT lymphocytes subpoplation except CD4+CD45RO+ and natural killer cell. Pb concentration was only statisticalsignificance with total lymphocytes. Our results suggest that occupationally exposed to Mn and Pb can affectthe cellular immune response. 요약: 이 연구는 Mn과 Pb의 노출이 면역체계에 미치는 영향을 파악하고자 하였다. 연구대상자는 남성근로자 42 명으로, 대상자 중 13명은 사무직 근로자(실험군 I), 21 명은 제조업 사업장 근로자(실험군 II), 8명은 용접 작업자(실험군 III)였다. 대상자의 혈액 중 Mn과 Pb 농도는 실험군별로 유의한 차이를 보였다.실험군 I 대상자의 CD19+와 total lymphocytes 농도는 기타의 실험군 대상자에서보다 유의하게 높았으나 다른 T lymphocytes subpopulation의 농도는 차이가 없었다. Mn과 Pb 농도는 T lymphocytes subpopulation과음의 상관관계를 보였으나, Mn은 CD4+CD45RO+와 자연살해세포를 제외한 T lymphocytes subpopulation과유의한 음의 상관관계를 보였다. Pb 농도는 단지 total lymphocytes 농도와 유의한 음의 상관관계를 보였다. 이 연구에서 Mn과 Pb의 직업적인 노출은 세포성면역계에 영향을 미칠 수 있음을 제시하였다. Key words: immune system, T lymphocytes subpopulation, immunoglobulins, manganese, lead" @default.
- W2014003433 created "2016-06-24" @default.
- W2014003433 creator A5040566753 @default.
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- W2014003433 date "2014-10-25" @default.
- W2014003433 modified "2023-09-22" @default.
- W2014003433 title "Effects of low-level exposure to manganese and lead on immune function" @default.
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- W2014003433 doi "https://doi.org/10.5806/ast.2014.27.5.248" @default.
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