FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014005071> ?p ?o ?g. }

• W2014005071 endingPage "333" @default.
• W2014005071 startingPage "324" @default.
• W2014005071 abstract "The objective of this study was to assess the relative usefulness of canine versus in vitro data sets in the prediction of absorption of L-sulpiride (a low permeability compound) from an immediate and an extended release formulation. To reduce species differences on upper gastrointestinal residence times, human and canine data were collected in the fed state. In vitro permeability data (that were additionally confirmed by rat perfusion data) were obtained from the literature. In vitro release data were obtained in media simulating the gastric composition (without and with simultaneous protein digestion) and intestinal composition in the fed state. The results showed that, regardless of the formulation, canine input profiles were vastly different from human profiles at times longer than 2h after administration and led to 2.7 times higher total amount absorbed in dogs. In contrast, reliable in vitro permeability data in combination with in vitro release data collected in biorelevant media led to successful prediction of the human input profile; regardless of the dosage form, simulated and actual mean input profiles differed by less than 20%." @default.
• W2014005071 created "2016-06-24" @default.
• W2014005071 creator A5038097746 @default.
• W2014005071 creator A5072811095 @default.
• W2014005071 creator A5072939921 @default.
• W2014005071 date "2005-11-01" @default.
• W2014005071 modified "2023-10-07" @default.
• W2014005071 title "Canine versus in vitro data for predicting input profiles of l-sulpiride after oral administration" @default.
• W2014005071 cites W1498305210 @default.
• W2014005071 cites W1499768710 @default.
• W2014005071 cites W1499935265 @default.
• W2014005071 cites W1508131850 @default.
• W2014005071 cites W1513692286 @default.
• W2014005071 cites W1552183320 @default.
• W2014005071 cites W1574019439 @default.
• W2014005071 cites W1605981446 @default.
• W2014005071 cites W1898944809 @default.
• W2014005071 cites W1905174418 @default.
• W2014005071 cites W1968729081 @default.
• W2014005071 cites W1969664462 @default.
• W2014005071 cites W1972362674 @default.
• W2014005071 cites W1975460741 @default.
• W2014005071 cites W1991389164 @default.
• W2014005071 cites W1996280064 @default.
• W2014005071 cites W1997911205 @default.
• W2014005071 cites W2012502072 @default.
• W2014005071 cites W2015005952 @default.
• W2014005071 cites W2018206163 @default.
• W2014005071 cites W2019374159 @default.
• W2014005071 cites W2021482497 @default.
• W2014005071 cites W2022500225 @default.
• W2014005071 cites W2022898836 @default.
• W2014005071 cites W2029156005 @default.
• W2014005071 cites W2045664150 @default.
• W2014005071 cites W2048643382 @default.
• W2014005071 cites W2051126200 @default.
• W2014005071 cites W2052336326 @default.
• W2014005071 cites W2061244298 @default.
• W2014005071 cites W2065240317 @default.
• W2014005071 cites W2070305054 @default.
• W2014005071 cites W2080068747 @default.
• W2014005071 cites W2082482660 @default.
• W2014005071 cites W2082816879 @default.
• W2014005071 cites W2093328959 @default.
• W2014005071 cites W2094504082 @default.
• W2014005071 cites W2113953460 @default.
• W2014005071 cites W2122768566 @default.
• W2014005071 cites W2171331438 @default.
• W2014005071 cites W2419800446 @default.
• W2014005071 cites W252369352 @default.
• W2014005071 cites W2941696551 @default.
• W2014005071 cites W4299615643 @default.
• W2014005071 cites W98949241 @default.
• W2014005071 doi "https://doi.org/10.1016/j.ejps.2005.07.004" @default.
• W2014005071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16139490" @default.
• W2014005071 hasPublicationYear "2005" @default.
• W2014005071 type Work @default.
• W2014005071 sameAs 2014005071 @default.
• W2014005071 citedByCount "46" @default.
• W2014005071 countsByYear W20140050712012 @default.
• W2014005071 countsByYear W20140050712013 @default.
• W2014005071 countsByYear W20140050712014 @default.
• W2014005071 countsByYear W20140050712015 @default.
• W2014005071 countsByYear W20140050712016 @default.
• W2014005071 countsByYear W20140050712017 @default.
• W2014005071 countsByYear W20140050712021 @default.
• W2014005071 countsByYear W20140050712022 @default.
• W2014005071 crossrefType "journal-article" @default.
• W2014005071 hasAuthorship W2014005071A5038097746 @default.
• W2014005071 hasAuthorship W2014005071A5072811095 @default.
• W2014005071 hasAuthorship W2014005071A5072939921 @default.
• W2014005071 hasConcept C120882062 @default.
• W2014005071 hasConcept C126322002 @default.
• W2014005071 hasConcept C146957229 @default.
• W2014005071 hasConcept C170493617 @default.
• W2014005071 hasConcept C185592680 @default.
• W2014005071 hasConcept C202751555 @default.
• W2014005071 hasConcept C2776885963 @default.
• W2014005071 hasConcept C2780806966 @default.
• W2014005071 hasConcept C41625074 @default.
• W2014005071 hasConcept C43617362 @default.
• W2014005071 hasConcept C55493867 @default.
• W2014005071 hasConcept C71924100 @default.
• W2014005071 hasConceptScore W2014005071C120882062 @default.
• W2014005071 hasConceptScore W2014005071C126322002 @default.
• W2014005071 hasConceptScore W2014005071C146957229 @default.
• W2014005071 hasConceptScore W2014005071C170493617 @default.
• W2014005071 hasConceptScore W2014005071C185592680 @default.
• W2014005071 hasConceptScore W2014005071C202751555 @default.
• W2014005071 hasConceptScore W2014005071C2776885963 @default.
• W2014005071 hasConceptScore W2014005071C2780806966 @default.
• W2014005071 hasConceptScore W2014005071C41625074 @default.
• W2014005071 hasConceptScore W2014005071C43617362 @default.
• W2014005071 hasConceptScore W2014005071C55493867 @default.
• W2014005071 hasConceptScore W2014005071C71924100 @default.
• W2014005071 hasIssue "3-4" @default.
• W2014005071 hasLocation W20140050711 @default.
• W2014005071 hasLocation W20140050712 @default.

• next