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- W2014005462 abstract "To examine the features of major congenital heart disease (CHD) diagnosed by early fetal echocardiography in chromosomally normal fetuses. During a five-year period, 24 major CHD were detected in pregnant women undergoing fetal echocardiography at 11 to 14 weeks because of high risk for CHD, and in whom aneuploidy had been ruled out. Transvaginal ultrasound was the preferred approach and colour and pulsed Doppler examination were always used. Whenever a normal early scan was found, a further fetal echocardiography at 20–22 weeks was performed. Reliability was assessed by postnatal follow-up or autopsy in the case of termination of pregnancy or perinatal death. The 24 major CHD detected were the following: hypoplastic left heart syndrome (n = 7), atrioventricular septal defect (n = 6), tetralogy of Fallot (n = 4), transposition of the great arteries (n = 3), hypoplastic right heart syndrome (n = 3) and a ventricular diverticle + VSD. The main indication for study was the finding of increased NT≥ 99th centile in 16 cases (67%), while a suspicion of anomaly in the 11–14 weeks' screening scan accounted for seven cases (29%) and an isolated reverse flow in the ductus venosus for the last one (4%). The median gestational age at diagnosis was 13 weeks, with just two cases diagnosed at 12 weeks and none at 11 weeks. The median NT was 5.6 (range, 3.3–11.7) mm. We were able to affirm normality in the remaining normal cases, with neither false positive or negative results for major defects. Two further clinically asymptomatic minor defects were detected postnatally: a small VSD and an aortic insufficiency. Early fetal echocardiography is very accurate beyond the 12th week of gestation, thus should be offered in high-risk populations. The finding of an increased NT is the strongest predictor of CHD at this time of pregnancy." @default.
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- W2014005462 date "2007-09-21" @default.
- W2014005462 modified "2023-09-26" @default.
- W2014005462 title "OP12.13: Diagnosis of congenital heart disease at 11-14 weeks in fetuses with normal karyotype" @default.
- W2014005462 doi "https://doi.org/10.1002/uog.4529" @default.
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