FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014006553> ?p ?o ?g. }

• W2014006553 endingPage "1579" @default.
• W2014006553 startingPage "1574" @default.
• W2014006553 abstract "The Coxsackie and adenovirus receptor (CAR) has been shown to inhibit cancer cell proliferation, migration, and invasion. The underlying mechanisms, however, are poorly understood.The differential gene expression in the human colon cancer cell line DLD1 on RNAi-mediated functional CAR knockdown was analysed using oligo-array technology. Expression of alpha-catenin was determined by quantitative RT-PCR and western blotting. Proliferation, migration, and invasion after CAR knockdown were assessed by in vitro assays, and cell morphology in a three-dimensional context was evaluated using matrigel.Oligo-array technology identified alpha-catenin as the strongest downregulated gene after CAR knockdown. Western blotting and quantitative RT-PCR confirmed a reduced alpha-catenin expression after CAR knockdown in DLD1 cells and in the rat intestinal cell line IEC-6. Functionally, both cell lines showed a marked increase in proliferation, migration, and invasion on CAR knockdown. In matrigel, both cell lines formed amorphous cell clusters in contrast to well-organised three-dimensional structures of CAR-expressing vector controls. Ectopic 're'-expression of alpha-catenin in DLD1 and IEC-6 CAR knockdown cells reversed these functional and morphological effects.These data suggest that an interaction of CAR and alpha-catenin mediates the impact of CAR on cell proliferation, migration, invasion, and morphology." @default.
• W2014006553 created "2016-06-24" @default.
• W2014006553 creator A5007891817 @default.
• W2014006553 creator A5063520231 @default.
• W2014006553 creator A5081849815 @default.
• W2014006553 creator A5088959005 @default.
• W2014006553 date "2009-09-22" @default.
• W2014006553 modified "2023-10-06" @default.
• W2014006553 title "Loss of Coxsackie and adenovirus receptor downregulates α-catenin expression" @default.
• W2014006553 cites W157725706 @default.
• W2014006553 cites W1963910714 @default.
• W2014006553 cites W1974080806 @default.
• W2014006553 cites W1984402213 @default.
• W2014006553 cites W2002507699 @default.
• W2014006553 cites W2004109703 @default.
• W2014006553 cites W2008078589 @default.
• W2014006553 cites W2013394636 @default.
• W2014006553 cites W2031068361 @default.
• W2014006553 cites W2037262542 @default.
• W2014006553 cites W2048142299 @default.
• W2014006553 cites W2059510767 @default.
• W2014006553 cites W2069411014 @default.
• W2014006553 cites W2078549990 @default.
• W2014006553 cites W2079749916 @default.
• W2014006553 cites W2095140635 @default.
• W2014006553 cites W2127340798 @default.
• W2014006553 cites W2170161136 @default.
• W2014006553 doi "https://doi.org/10.1038/sj.bjc.6605331" @default.
• W2014006553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2778516" @default.
• W2014006553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19773761" @default.
• W2014006553 hasPublicationYear "2009" @default.
• W2014006553 type Work @default.
• W2014006553 sameAs 2014006553 @default.
• W2014006553 citedByCount "16" @default.
• W2014006553 countsByYear W20140065532012 @default.
• W2014006553 countsByYear W20140065532014 @default.
• W2014006553 countsByYear W20140065532015 @default.
• W2014006553 countsByYear W20140065532016 @default.
• W2014006553 countsByYear W20140065532017 @default.
• W2014006553 countsByYear W20140065532019 @default.
• W2014006553 countsByYear W20140065532022 @default.
• W2014006553 countsByYear W20140065532023 @default.
• W2014006553 crossrefType "journal-article" @default.
• W2014006553 hasAuthorship W2014006553A5007891817 @default.
• W2014006553 hasAuthorship W2014006553A5063520231 @default.
• W2014006553 hasAuthorship W2014006553A5081849815 @default.
• W2014006553 hasAuthorship W2014006553A5088959005 @default.
• W2014006553 hasBestOaLocation W20140065531 @default.
• W2014006553 hasConcept C104317684 @default.
• W2014006553 hasConcept C137620995 @default.
• W2014006553 hasConcept C153911025 @default.
• W2014006553 hasConcept C173396325 @default.
• W2014006553 hasConcept C185592680 @default.
• W2014006553 hasConcept C2778608917 @default.
• W2014006553 hasConcept C502942594 @default.
• W2014006553 hasConcept C54355233 @default.
• W2014006553 hasConcept C62112901 @default.
• W2014006553 hasConcept C62478195 @default.
• W2014006553 hasConcept C81885089 @default.
• W2014006553 hasConcept C85265743 @default.
• W2014006553 hasConcept C86803240 @default.
• W2014006553 hasConcept C95444343 @default.
• W2014006553 hasConcept C97037327 @default.
• W2014006553 hasConceptScore W2014006553C104317684 @default.
• W2014006553 hasConceptScore W2014006553C137620995 @default.
• W2014006553 hasConceptScore W2014006553C153911025 @default.
• W2014006553 hasConceptScore W2014006553C173396325 @default.
• W2014006553 hasConceptScore W2014006553C185592680 @default.
• W2014006553 hasConceptScore W2014006553C2778608917 @default.
• W2014006553 hasConceptScore W2014006553C502942594 @default.
• W2014006553 hasConceptScore W2014006553C54355233 @default.
• W2014006553 hasConceptScore W2014006553C62112901 @default.
• W2014006553 hasConceptScore W2014006553C62478195 @default.
• W2014006553 hasConceptScore W2014006553C81885089 @default.
• W2014006553 hasConceptScore W2014006553C85265743 @default.
• W2014006553 hasConceptScore W2014006553C86803240 @default.
• W2014006553 hasConceptScore W2014006553C95444343 @default.
• W2014006553 hasConceptScore W2014006553C97037327 @default.
• W2014006553 hasIssue "9" @default.
• W2014006553 hasLocation W20140065531 @default.
• W2014006553 hasLocation W20140065532 @default.
• W2014006553 hasLocation W20140065533 @default.
• W2014006553 hasLocation W20140065534 @default.
• W2014006553 hasOpenAccess W2014006553 @default.
• W2014006553 hasPrimaryLocation W20140065531 @default.
• W2014006553 hasRelatedWork W2128946898 @default.
• W2014006553 hasRelatedWork W2613842309 @default.
• W2014006553 hasRelatedWork W2699522849 @default.
• W2014006553 hasRelatedWork W2884889442 @default.
• W2014006553 hasRelatedWork W2912099029 @default.
• W2014006553 hasRelatedWork W2920999680 @default.
• W2014006553 hasRelatedWork W2980955790 @default.
• W2014006553 hasRelatedWork W3125058930 @default.
• W2014006553 hasRelatedWork W4309663334 @default.
• W2014006553 hasRelatedWork W4322718626 @default.
• W2014006553 hasVolume "101" @default.
• W2014006553 isParatext "false" @default.
• W2014006553 isRetracted "false" @default.

• next