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- W2014009683 abstract "The sensitising effect of the hypoxic cell sensitiser misonidazole (MIS) on NHIK 1922 cells irradiated either as single cells in vitro or as tumours in vivo in air-breathing and in dead mice was investigated with subsequent determination of in vitro colony-forming ability. In absence of MIS no significant difference was found between the dose-response curves after irradiation of tumours in dead mice and of cells in suspension under hypoxic conditions. After irradiation of tumours in air-breathing mice the same enhancement ratio of 1.4 was found whether MIS was administered in doses of 250 or 1000 micrograms/g body weight. In dead mice the enhancement ratio was 1.3 and 2.6 after 250 and 1000 micrograms/g, respectively. The sensitising effect of MIS for cells irradiated in suspension under extremely hypoxic conditions corresponded to that found in dead mice when a comparable concentration of MIS was used." @default.
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- W2014009683 title "Sensitising Effect of Misonidazole on Nhik 1922 Cells Irradiated in Vitro or as Solid Tumour in Athymic Nude Mice" @default.
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- W2014009683 doi "https://doi.org/10.3109/02841868109130428" @default.
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