FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014011681> ?p ?o ?g. }

• W2014011681 endingPage "31" @default.
• W2014011681 startingPage "31" @default.
• W2014011681 abstract "Predictors of premature discontinuation of treatment in multiple disease states Eric Nantz1, Hong Liu-Seifert2, Vladimir Skljarevski21Department of Statistics, Western Michigan University, Kalamazoo, MI, USA; 2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USABackground: Premature discontinuation of treatment impacts outcomes of clinical practice. The traditional perception has been patient discontinuation is mainly driven by unwanted side effects. Systematic analysis of data from clinical trials across several disease states was performed to identify predictors of premature discontinuation during clinical interventions.Methods: A post hoc analysis was conducted on 22 randomized, double-blind, placebo-controlled clinical trials for treatment of fibromyalgia, diabetic peripheral neuropathic pain, major depressive disorder, and generalized anxiety disorder. Analyses were conducted on pooled data within each disease state.Results: Lack of early therapeutic response was a significant predictor of patient discontinuation in each disease state. Visit-wise changes in therapeutic response and severity of adverse events were also significant risk factors, with change in therapeutic response having a higher significance level in three disease states. Patients who discontinued due to adverse events had similar therapeutic responses as patients completing treatment.Conclusion: Contrary to the conventional belief that premature treatment discontinuation is primarily related to adverse events, our findings suggest lack of therapeutic response also plays a significant role in patient attrition. This research highlights the importance of systematic monitoring of therapeutic response in clinical practice as a measure to prevent patients’ discontinuation from pharmacological treatments.Keywords: attrition, depression, generalized anxiety disorder, fibromyalgia, therapeutic response, adverse event" @default.
• W2014011681 created "2016-06-24" @default.
• W2014011681 creator A5045897473 @default.
• W2014011681 creator A5055441251 @default.
• W2014011681 creator A5085051732 @default.
• W2014011681 date "2009-01-01" @default.
• W2014011681 modified "2023-10-10" @default.
• W2014011681 title "Predictors of premature discontinuation of treatment in multiple disease states" @default.
• W2014011681 cites W1604217211 @default.
• W2014011681 cites W1972387365 @default.
• W2014011681 cites W1975916217 @default.
• W2014011681 cites W1990660816 @default.
• W2014011681 cites W1992436256 @default.
• W2014011681 cites W1997499592 @default.
• W2014011681 cites W2001358605 @default.
• W2014011681 cites W2009137120 @default.
• W2014011681 cites W2012721279 @default.
• W2014011681 cites W2034884858 @default.
• W2014011681 cites W2036851003 @default.
• W2014011681 cites W2040179400 @default.
• W2014011681 cites W2042071004 @default.
• W2014011681 cites W2042510791 @default.
• W2014011681 cites W2049025206 @default.
• W2014011681 cites W2053043565 @default.
• W2014011681 cites W2067395472 @default.
• W2014011681 cites W2092957075 @default.
• W2014011681 cites W2106059433 @default.
• W2014011681 cites W2132270420 @default.
• W2014011681 cites W2144939848 @default.
• W2014011681 cites W2160571019 @default.
• W2014011681 cites W2172185379 @default.
• W2014011681 cites W2487771920 @default.
• W2014011681 doi "https://doi.org/10.2147/ppa.s4633" @default.
• W2014011681 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2778422" @default.
• W2014011681 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19936143" @default.
• W2014011681 hasPublicationYear "2009" @default.
• W2014011681 type Work @default.
• W2014011681 sameAs 2014011681 @default.
• W2014011681 citedByCount "25" @default.
• W2014011681 countsByYear W20140116812012 @default.
• W2014011681 countsByYear W20140116812013 @default.
• W2014011681 countsByYear W20140116812014 @default.
• W2014011681 countsByYear W20140116812015 @default.
• W2014011681 countsByYear W20140116812016 @default.
• W2014011681 countsByYear W20140116812017 @default.
• W2014011681 countsByYear W20140116812021 @default.
• W2014011681 countsByYear W20140116812023 @default.
• W2014011681 crossrefType "journal-article" @default.
• W2014011681 hasAuthorship W2014011681A5045897473 @default.
• W2014011681 hasAuthorship W2014011681A5055441251 @default.
• W2014011681 hasAuthorship W2014011681A5085051732 @default.
• W2014011681 hasBestOaLocation W20140116811 @default.
• W2014011681 hasConcept C118552586 @default.
• W2014011681 hasConcept C126322002 @default.
• W2014011681 hasConcept C139719470 @default.
• W2014011681 hasConcept C142724271 @default.
• W2014011681 hasConcept C162324750 @default.
• W2014011681 hasConcept C177713679 @default.
• W2014011681 hasConcept C1862650 @default.
• W2014011681 hasConcept C197934379 @default.
• W2014011681 hasConcept C204787440 @default.
• W2014011681 hasConcept C27081682 @default.
• W2014011681 hasConcept C2776867660 @default.
• W2014011681 hasConcept C2777831278 @default.
• W2014011681 hasConcept C2778715236 @default.
• W2014011681 hasConcept C2779134260 @default.
• W2014011681 hasConcept C535046627 @default.
• W2014011681 hasConcept C558461103 @default.
• W2014011681 hasConcept C71924100 @default.
• W2014011681 hasConceptScore W2014011681C118552586 @default.
• W2014011681 hasConceptScore W2014011681C126322002 @default.
• W2014011681 hasConceptScore W2014011681C139719470 @default.
• W2014011681 hasConceptScore W2014011681C142724271 @default.
• W2014011681 hasConceptScore W2014011681C162324750 @default.
• W2014011681 hasConceptScore W2014011681C177713679 @default.
• W2014011681 hasConceptScore W2014011681C1862650 @default.
• W2014011681 hasConceptScore W2014011681C197934379 @default.
• W2014011681 hasConceptScore W2014011681C204787440 @default.
• W2014011681 hasConceptScore W2014011681C27081682 @default.
• W2014011681 hasConceptScore W2014011681C2776867660 @default.
• W2014011681 hasConceptScore W2014011681C2777831278 @default.
• W2014011681 hasConceptScore W2014011681C2778715236 @default.
• W2014011681 hasConceptScore W2014011681C2779134260 @default.
• W2014011681 hasConceptScore W2014011681C535046627 @default.
• W2014011681 hasConceptScore W2014011681C558461103 @default.
• W2014011681 hasConceptScore W2014011681C71924100 @default.
• W2014011681 hasLocation W20140116811 @default.
• W2014011681 hasLocation W20140116812 @default.
• W2014011681 hasLocation W20140116813 @default.
• W2014011681 hasLocation W20140116814 @default.
• W2014011681 hasOpenAccess W2014011681 @default.
• W2014011681 hasPrimaryLocation W20140116811 @default.
• W2014011681 hasRelatedWork W2085830368 @default.
• W2014011681 hasRelatedWork W2360693916 @default.
• W2014011681 hasRelatedWork W2415484199 @default.
• W2014011681 hasRelatedWork W2419505618 @default.
• W2014011681 hasRelatedWork W3121096891 @default.
• W2014011681 hasRelatedWork W3161575893 @default.

• next