Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014012004> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2014012004 abstract "Multidrug resistance (MDR) is a common problem in various types of cancer. One important factor in the development of MDR is overexpression of P-glycoprotein, encoded by the MDR1 gene. Morphine is the opioid of choice for moderate to severe cancer pain, and is a substrate of P-glycoprotein. Recently, morphine has been shown to induce P-glycoprotein expression in the rat brain. Using Western blot analysis and cytotoxicity assays respectively, we have investigated the effects of short-term (72 h) morphine treatment on P-glycoprotein expression in a panel of human cancer cell lines, and its effects on cellular resistance to the known P-glycoprotein substrates, vinblastine and colchicine. The effect of morphine on P-glycoprotein expression and activity in the mouse fibroblast NIH-3T3 cell was assessed to establish whether morphine effects are species specific. Short-term exposure to morphine did not result in any significant differences in P-glycoprotein expression or activity in any cancer cell lines. Morphine pre-treatment resulted in a moderate but significant increase in sensitivity of NIH-3T3 cells to vinblastine, but not colchicine. This study suggests that morphine effects may be cell-type specific. Importantly, however, it appears that short-term morphine treatment does not affect the MDR phenotype of tumour cells." @default.
- W2014012004 created "2016-06-24" @default.
- W2014012004 creator A5018463878 @default.
- W2014012004 creator A5018610727 @default.
- W2014012004 creator A5056468592 @default.
- W2014012004 creator A5073106472 @default.
- W2014012004 creator A5083099452 @default.
- W2014012004 date "2004-05-01" @default.
- W2014012004 modified "2023-09-27" @default.
- W2014012004 title "Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines" @default.
- W2014012004 doi "https://doi.org/10.3892/or.11.5.1091" @default.
- W2014012004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15069552" @default.
- W2014012004 hasPublicationYear "2004" @default.
- W2014012004 type Work @default.
- W2014012004 sameAs 2014012004 @default.
- W2014012004 citedByCount "1" @default.
- W2014012004 countsByYear W20140120042017 @default.
- W2014012004 crossrefType "journal-article" @default.
- W2014012004 hasAuthorship W2014012004A5018463878 @default.
- W2014012004 hasAuthorship W2014012004A5018610727 @default.
- W2014012004 hasAuthorship W2014012004A5056468592 @default.
- W2014012004 hasAuthorship W2014012004A5073106472 @default.
- W2014012004 hasAuthorship W2014012004A5083099452 @default.
- W2014012004 hasConcept C114851261 @default.
- W2014012004 hasConcept C121608353 @default.
- W2014012004 hasConcept C126322002 @default.
- W2014012004 hasConcept C133936738 @default.
- W2014012004 hasConcept C1491633281 @default.
- W2014012004 hasConcept C2776636253 @default.
- W2014012004 hasConcept C2776694085 @default.
- W2014012004 hasConcept C2777132456 @default.
- W2014012004 hasConcept C2777389121 @default.
- W2014012004 hasConcept C2778707650 @default.
- W2014012004 hasConcept C2781018059 @default.
- W2014012004 hasConcept C29537977 @default.
- W2014012004 hasConcept C502942594 @default.
- W2014012004 hasConcept C54355233 @default.
- W2014012004 hasConcept C55493867 @default.
- W2014012004 hasConcept C71924100 @default.
- W2014012004 hasConcept C81885089 @default.
- W2014012004 hasConcept C86803240 @default.
- W2014012004 hasConcept C89423630 @default.
- W2014012004 hasConcept C96232424 @default.
- W2014012004 hasConcept C98274493 @default.
- W2014012004 hasConceptScore W2014012004C114851261 @default.
- W2014012004 hasConceptScore W2014012004C121608353 @default.
- W2014012004 hasConceptScore W2014012004C126322002 @default.
- W2014012004 hasConceptScore W2014012004C133936738 @default.
- W2014012004 hasConceptScore W2014012004C1491633281 @default.
- W2014012004 hasConceptScore W2014012004C2776636253 @default.
- W2014012004 hasConceptScore W2014012004C2776694085 @default.
- W2014012004 hasConceptScore W2014012004C2777132456 @default.
- W2014012004 hasConceptScore W2014012004C2777389121 @default.
- W2014012004 hasConceptScore W2014012004C2778707650 @default.
- W2014012004 hasConceptScore W2014012004C2781018059 @default.
- W2014012004 hasConceptScore W2014012004C29537977 @default.
- W2014012004 hasConceptScore W2014012004C502942594 @default.
- W2014012004 hasConceptScore W2014012004C54355233 @default.
- W2014012004 hasConceptScore W2014012004C55493867 @default.
- W2014012004 hasConceptScore W2014012004C71924100 @default.
- W2014012004 hasConceptScore W2014012004C81885089 @default.
- W2014012004 hasConceptScore W2014012004C86803240 @default.
- W2014012004 hasConceptScore W2014012004C89423630 @default.
- W2014012004 hasConceptScore W2014012004C96232424 @default.
- W2014012004 hasConceptScore W2014012004C98274493 @default.
- W2014012004 hasLocation W20140120041 @default.
- W2014012004 hasLocation W20140120042 @default.
- W2014012004 hasOpenAccess W2014012004 @default.
- W2014012004 hasPrimaryLocation W20140120041 @default.
- W2014012004 hasRelatedWork W1514682355 @default.
- W2014012004 hasRelatedWork W1981376295 @default.
- W2014012004 hasRelatedWork W1981670710 @default.
- W2014012004 hasRelatedWork W2020904161 @default.
- W2014012004 hasRelatedWork W2030087686 @default.
- W2014012004 hasRelatedWork W2046189325 @default.
- W2014012004 hasRelatedWork W2059471162 @default.
- W2014012004 hasRelatedWork W2066809274 @default.
- W2014012004 hasRelatedWork W2080763252 @default.
- W2014012004 hasRelatedWork W2100416787 @default.
- W2014012004 hasRelatedWork W2107456780 @default.
- W2014012004 hasRelatedWork W2118498980 @default.
- W2014012004 hasRelatedWork W2138138876 @default.
- W2014012004 hasRelatedWork W2142138315 @default.
- W2014012004 hasRelatedWork W2169081155 @default.
- W2014012004 hasRelatedWork W2169244399 @default.
- W2014012004 hasRelatedWork W2338332545 @default.
- W2014012004 hasRelatedWork W2417709348 @default.
- W2014012004 hasRelatedWork W2438735425 @default.
- W2014012004 hasRelatedWork W2885472956 @default.
- W2014012004 isParatext "false" @default.
- W2014012004 isRetracted "false" @default.
- W2014012004 magId "2014012004" @default.
- W2014012004 workType "article" @default.