FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014013280> ?p ?o ?g. }

• W2014013280 endingPage "14" @default.
• W2014013280 startingPage "1" @default.
• W2014013280 abstract "The response of cells to stress was first documented in the 1960s and 1970s and the molecular nature of the families of proteins that subserve this vital response, the molecular chaperones, were identified and subjected to critical study in the period from the late 1980s. This resulted in the rapidly advancing new field of protein folding and its role in cellular function. Emerging at the same time, but initially largely ignored, were reports that molecular chaperones could be released by cells and exist on the outer plasma membrane or in the body fluids. These secreted molecular chaperones were found to have intercellular signalling functions. There is now a growing body of evidence to support the hypothesis that molecular chaperones have properties ascribed to the Roman god Janus, the god of gates, doors, beginnings and endings, whose two faces point in different directions. Molecular chaperones appear to have one set of key functions within the cell and, potentially, a separate set of functions when they exist on the cell surface or in the various fluid phases of the body. Thus, it is a likely hypothesis that secreted molecular chaperones act as an additional level of homeostatic control possibly linking cellular stress to physiological systems such as the immune system. This review concentrates on three key molecular chaperones: Hsp10, Hsp60 and the Hsp70 family for which most information is available. An important consideration is the role that these proteins may play in human disease and in the treatment of human disease. Copyright © 2009 John Wiley & Sons, Ltd." @default.
• W2014013280 created "2016-06-24" @default.
• W2014013280 creator A5063065323 @default.
• W2014013280 date "2010-01-01" @default.
• W2014013280 modified "2023-09-25" @default.
• W2014013280 title "Integrating the cell stress response: a new view of molecular chaperones as immunological and physiological homeostatic regulators" @default.
• W2014013280 cites W1504160997 @default.
• W2014013280 cites W1507205945 @default.
• W2014013280 cites W1510585824 @default.
• W2014013280 cites W1515599953 @default.
• W2014013280 cites W1518351006 @default.
• W2014013280 cites W1535222299 @default.
• W2014013280 cites W1546651636 @default.
• W2014013280 cites W1547018200 @default.
• W2014013280 cites W1553853809 @default.
• W2014013280 cites W1555650656 @default.
• W2014013280 cites W1584629476 @default.
• W2014013280 cites W1585651039 @default.
• W2014013280 cites W1587522694 @default.
• W2014013280 cites W1588574695 @default.
• W2014013280 cites W1591714343 @default.
• W2014013280 cites W1624946627 @default.
• W2014013280 cites W1684431858 @default.
• W2014013280 cites W1687473291 @default.
• W2014013280 cites W1809540926 @default.
• W2014013280 cites W1820973630 @default.
• W2014013280 cites W1899375067 @default.
• W2014013280 cites W1919957390 @default.
• W2014013280 cites W1922446009 @default.
• W2014013280 cites W1964567745 @default.
• W2014013280 cites W1967879350 @default.
• W2014013280 cites W1969052889 @default.
• W2014013280 cites W1969062558 @default.
• W2014013280 cites W1971756409 @default.
• W2014013280 cites W1973379089 @default.
• W2014013280 cites W1973661844 @default.
• W2014013280 cites W1976664716 @default.
• W2014013280 cites W1977759832 @default.
• W2014013280 cites W1978441612 @default.
• W2014013280 cites W1982697672 @default.
• W2014013280 cites W1983443046 @default.
• W2014013280 cites W1988314519 @default.
• W2014013280 cites W1992038098 @default.
• W2014013280 cites W1992038850 @default.
• W2014013280 cites W1996486842 @default.
• W2014013280 cites W2001015172 @default.
• W2014013280 cites W2003882208 @default.
• W2014013280 cites W2005053745 @default.
• W2014013280 cites W2005570998 @default.
• W2014013280 cites W2007791611 @default.
• W2014013280 cites W2008980402 @default.
• W2014013280 cites W2011429076 @default.
• W2014013280 cites W2011641581 @default.
• W2014013280 cites W2011746015 @default.
• W2014013280 cites W2015535625 @default.
• W2014013280 cites W2016671523 @default.
• W2014013280 cites W2020126424 @default.
• W2014013280 cites W2023395434 @default.
• W2014013280 cites W2026848174 @default.
• W2014013280 cites W2028017703 @default.
• W2014013280 cites W2028874474 @default.
• W2014013280 cites W2032942842 @default.
• W2014013280 cites W2039897895 @default.
• W2014013280 cites W2043433277 @default.
• W2014013280 cites W2044167082 @default.
• W2014013280 cites W2046506832 @default.
• W2014013280 cites W2046595571 @default.
• W2014013280 cites W2047323360 @default.
• W2014013280 cites W2047477750 @default.
• W2014013280 cites W2049304590 @default.
• W2014013280 cites W2051619641 @default.
• W2014013280 cites W2055183780 @default.
• W2014013280 cites W2056120162 @default.
• W2014013280 cites W2057537467 @default.
• W2014013280 cites W2058481124 @default.
• W2014013280 cites W2060560636 @default.
• W2014013280 cites W2065635384 @default.
• W2014013280 cites W2065638048 @default.
• W2014013280 cites W2066418716 @default.
• W2014013280 cites W2067414008 @default.
• W2014013280 cites W2068332158 @default.
• W2014013280 cites W2070546639 @default.
• W2014013280 cites W2074901733 @default.
• W2014013280 cites W2075923636 @default.
• W2014013280 cites W2077388126 @default.
• W2014013280 cites W2078125361 @default.
• W2014013280 cites W2080352912 @default.
• W2014013280 cites W2083682196 @default.
• W2014013280 cites W2083856174 @default.
• W2014013280 cites W2087711149 @default.
• W2014013280 cites W2089400513 @default.
• W2014013280 cites W2090084038 @default.
• W2014013280 cites W2090551173 @default.
• W2014013280 cites W2094605832 @default.
• W2014013280 cites W2095736339 @default.
• W2014013280 cites W2098766459 @default.
• W2014013280 cites W2100431176 @default.
• W2014013280 cites W2100650245 @default.

• next