Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014014546> ?p ?o ?g. }
- W2014014546 endingPage "11" @default.
- W2014014546 startingPage "1" @default.
- W2014014546 abstract "Beta-amyloid peptide (Aβ) damage is one of major potential causes of Alzheimer's disease (AD) and its modulation has emerged as a promising approach to control the onset of AD. In the present study, the effects of oleic acid (OA) against Aβ25–35-stimulated neurotoxicity, inflammatory responses, and further molecular mechanism underlying the neuroprotective properties of OA in PC12 cells were investigated. Pre-treatment of OA significantly decreased Aβ25–35-mediated cytotoxicity by increasing cell viability through the attenuation of intracellular reactive oxygen species (ROS) level and downregulation of pro-apoptotic activated caspase-3, thereby mitigating apoptotic morphological alterations. Improper up-regulation of both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) by Aβ25–35 was significantly suppressed by preconditioning of OA through repression of the inhibitory unit I-κB degradation, which impedes subsequent nuclear translocation of the functionally active subunit of transcription factor nuclear factor-kappa B (NF-κB). OA noticeably attenuated Aβ25–35-stimulated phosphorylation of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun-N-terminal kinase (JNK). Taken together, these findings suggest that the mechanisms responsible for anti-apoptotic and anti-inflammatory properties of OA in Aβ25–35-mediated neuronal damage is associated with COX-2 and iNOS downregulation through activation of NF-κB mediated by upstream kinases including JNK, ERK and p38 MAPK." @default.
- W2014014546 created "2016-06-24" @default.
- W2014014546 creator A5008735600 @default.
- W2014014546 creator A5042552627 @default.
- W2014014546 creator A5058545518 @default.
- W2014014546 creator A5059989941 @default.
- W2014014546 creator A5070109176 @default.
- W2014014546 creator A5087401887 @default.
- W2014014546 creator A5091034884 @default.
- W2014014546 date "2015-04-01" @default.
- W2014014546 modified "2023-09-27" @default.
- W2014014546 title "Oleic acid ameliorates Aβ-induced inflammation by downregulation of COX-2 and iNOS via NFκB signaling pathway" @default.
- W2014014546 cites W1534988304 @default.
- W2014014546 cites W1900125011 @default.
- W2014014546 cites W1901276796 @default.
- W2014014546 cites W1960543132 @default.
- W2014014546 cites W1964511445 @default.
- W2014014546 cites W1971980150 @default.
- W2014014546 cites W1973975007 @default.
- W2014014546 cites W1974277301 @default.
- W2014014546 cites W1977877089 @default.
- W2014014546 cites W1979958463 @default.
- W2014014546 cites W1982871054 @default.
- W2014014546 cites W1983267906 @default.
- W2014014546 cites W1988991201 @default.
- W2014014546 cites W1989960241 @default.
- W2014014546 cites W1993649707 @default.
- W2014014546 cites W1996704273 @default.
- W2014014546 cites W1998836938 @default.
- W2014014546 cites W2003547729 @default.
- W2014014546 cites W2008649582 @default.
- W2014014546 cites W2011763578 @default.
- W2014014546 cites W2015640894 @default.
- W2014014546 cites W2021441921 @default.
- W2014014546 cites W2022577384 @default.
- W2014014546 cites W2022642951 @default.
- W2014014546 cites W2027065972 @default.
- W2014014546 cites W2041252693 @default.
- W2014014546 cites W2041836907 @default.
- W2014014546 cites W2047061114 @default.
- W2014014546 cites W2052513772 @default.
- W2014014546 cites W2058586845 @default.
- W2014014546 cites W2059214757 @default.
- W2014014546 cites W2062594697 @default.
- W2014014546 cites W2065619873 @default.
- W2014014546 cites W2073400782 @default.
- W2014014546 cites W2081028063 @default.
- W2014014546 cites W2083456498 @default.
- W2014014546 cites W2084617886 @default.
- W2014014546 cites W2085268591 @default.
- W2014014546 cites W2085373268 @default.
- W2014014546 cites W2090045283 @default.
- W2014014546 cites W2090703365 @default.
- W2014014546 cites W2101540253 @default.
- W2014014546 cites W2107737108 @default.
- W2014014546 cites W2114703626 @default.
- W2014014546 cites W2128171829 @default.
- W2014014546 cites W2128212086 @default.
- W2014014546 cites W2151892297 @default.
- W2014014546 cites W2159484834 @default.
- W2014014546 cites W2162497581 @default.
- W2014014546 cites W2554577986 @default.
- W2014014546 cites W35662498 @default.
- W2014014546 doi "https://doi.org/10.1016/j.jff.2015.01.027" @default.
- W2014014546 hasPublicationYear "2015" @default.
- W2014014546 type Work @default.
- W2014014546 sameAs 2014014546 @default.
- W2014014546 citedByCount "27" @default.
- W2014014546 countsByYear W20140145462015 @default.
- W2014014546 countsByYear W20140145462016 @default.
- W2014014546 countsByYear W20140145462017 @default.
- W2014014546 countsByYear W20140145462018 @default.
- W2014014546 countsByYear W20140145462019 @default.
- W2014014546 countsByYear W20140145462020 @default.
- W2014014546 countsByYear W20140145462021 @default.
- W2014014546 countsByYear W20140145462022 @default.
- W2014014546 countsByYear W20140145462023 @default.
- W2014014546 crossrefType "journal-article" @default.
- W2014014546 hasAuthorship W2014014546A5008735600 @default.
- W2014014546 hasAuthorship W2014014546A5042552627 @default.
- W2014014546 hasAuthorship W2014014546A5058545518 @default.
- W2014014546 hasAuthorship W2014014546A5059989941 @default.
- W2014014546 hasAuthorship W2014014546A5070109176 @default.
- W2014014546 hasAuthorship W2014014546A5087401887 @default.
- W2014014546 hasAuthorship W2014014546A5091034884 @default.
- W2014014546 hasConcept C104317684 @default.
- W2014014546 hasConcept C127561419 @default.
- W2014014546 hasConcept C181199279 @default.
- W2014014546 hasConcept C184235292 @default.
- W2014014546 hasConcept C185592680 @default.
- W2014014546 hasConcept C25498285 @default.
- W2014014546 hasConcept C2777622882 @default.
- W2014014546 hasConcept C2777730290 @default.
- W2014014546 hasConcept C51551487 @default.
- W2014014546 hasConcept C55493867 @default.
- W2014014546 hasConcept C57074206 @default.
- W2014014546 hasConcept C62478195 @default.
- W2014014546 hasConcept C86803240 @default.