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- W2014017128 abstract "Translocation of tRNAs through the ribosome is accompanied by large-scale rotation of the small ribosomal subunit relative to the large one. The interactions between the subunits have to be finely balanced to allow this high conformational flexibility while at the same time maintaining integrity of the ribosome complex. Here, we address the question of how the intersubunit interactions are fine-tuned by extensive all-atom, explicit solvent molecular dynamics simulations of the 70S ribosome starting from 13 distinct translocation intermediate models. These models were obtained by refining crystal structures against cryo-EM reconstructions of the spontaneoulsy translocating ribosome. Analysis of the trajectories at the residue level revealed two classes of intersubunit contact interactions: i) persistent residue contacts that are independent of intersubunit rotation and primarily located close to the axis of rotation. ii) contacts that are formed and ruptured depending on the rotation angle, seen mostly on the periphery. Strikingly, also these rotation specific contacts on the periphery substantially contribute to the overall stability of the ribosomal assembly and may serve to maintain a constant interaction energy with low barriers for rotation. Our simulations revealed that upon removal of tRNAs peripheral contacts are weakened and, in turn, intersubunit rotation angles decrease. This result is supported by recent cryo-EM data of tRNA depleted ribosomes and underlines the importance of these peripheral contacts." @default.
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- W2014017128 date "2014-01-01" @default.
- W2014017128 modified "2023-09-27" @default.
- W2014017128 title "Concerted Interactions between Ribosomal Subunits Allow for Large-Scale Rotations" @default.
- W2014017128 doi "https://doi.org/10.1016/j.bpj.2013.11.2748" @default.
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