FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014017310> ?p ?o ?g. }

• W2014017310 endingPage "451" @default.
• W2014017310 startingPage "439" @default.
• W2014017310 abstract "HIV-1 transactivator Tat has greatly contributed to our understanding of transcription elongation by RNAPII. We purified HIV-1 Tat-associated factors from HeLa nuclear extract and show that Tat forms two distinct and stable complexes. Tatcom1 consists of the core active P-TEFb, MLL-fusion partners involved in leukemia (AF9, AFF4, AFF1, ENL, and ELL), and PAF1 complex. Importantly, Tatcom1 formation relies on P-TEFb while optimal CDK9 CTD-kinase activity is AF9 dependent. MLL-fusion partners and PAF1 are required for Tat transactivation. Tatcom2 is composed of CDK9, CycT1, and 7SK snRNP lacking HEXIM. Tat remodels 7SK snRNP by interacting directly with 7SK RNA, leading to the formation of a stress-resistant 7SK snRNP particle. Besides the identification of factors required for Tat transactivation and important for P-TEFb function, our data show a coordinated control of RNAPII elongation by different classes of transcription elongation factors associated in a single complex and acting at the same promoter." @default.
• W2014017310 created "2016-06-24" @default.
• W2014017310 creator A5002801126 @default.
• W2014017310 creator A5004396985 @default.
• W2014017310 creator A5005368354 @default.
• W2014017310 creator A5012879670 @default.
• W2014017310 creator A5032148612 @default.
• W2014017310 creator A5042070411 @default.
• W2014017310 creator A5070645953 @default.
• W2014017310 date "2010-05-01" @default.
• W2014017310 modified "2023-10-13" @default.
• W2014017310 title "HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP" @default.
• W2014017310 cites W1542544035 @default.
• W2014017310 cites W1605366962 @default.
• W2014017310 cites W1640337477 @default.
• W2014017310 cites W1676133928 @default.
• W2014017310 cites W1813910892 @default.
• W2014017310 cites W1973462980 @default.
• W2014017310 cites W1976299815 @default.
• W2014017310 cites W1978884176 @default.
• W2014017310 cites W1979316039 @default.
• W2014017310 cites W1980199196 @default.
• W2014017310 cites W1987327863 @default.
• W2014017310 cites W1991914445 @default.
• W2014017310 cites W1992127633 @default.
• W2014017310 cites W2000742564 @default.
• W2014017310 cites W2000832682 @default.
• W2014017310 cites W2009403023 @default.
• W2014017310 cites W2014420355 @default.
• W2014017310 cites W2022936085 @default.
• W2014017310 cites W2034844305 @default.
• W2014017310 cites W2046854154 @default.
• W2014017310 cites W2048613921 @default.
• W2014017310 cites W2049874714 @default.
• W2014017310 cites W2051598492 @default.
• W2014017310 cites W2054006513 @default.
• W2014017310 cites W2057228860 @default.
• W2014017310 cites W2060200124 @default.
• W2014017310 cites W2060323540 @default.
• W2014017310 cites W2063738914 @default.
• W2014017310 cites W2069200751 @default.
• W2014017310 cites W2073652391 @default.
• W2014017310 cites W2079156590 @default.
• W2014017310 cites W2080834951 @default.
• W2014017310 cites W2081064241 @default.
• W2014017310 cites W2089422977 @default.
• W2014017310 cites W2096858144 @default.
• W2014017310 cites W2100973614 @default.
• W2014017310 cites W2103626942 @default.
• W2014017310 cites W2105085478 @default.
• W2014017310 cites W2108443798 @default.
• W2014017310 cites W2117789816 @default.
• W2014017310 cites W2125386151 @default.
• W2014017310 cites W2133938268 @default.
• W2014017310 cites W2144345042 @default.
• W2014017310 cites W2152258603 @default.
• W2014017310 cites W2152855058 @default.
• W2014017310 cites W2159591714 @default.
• W2014017310 cites W2163344214 @default.
• W2014017310 cites W2166730037 @default.
• W2014017310 cites W4250264720 @default.
• W2014017310 doi "https://doi.org/10.1016/j.molcel.2010.04.012" @default.
• W2014017310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3595998" @default.
• W2014017310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20471949" @default.
• W2014017310 hasPublicationYear "2010" @default.
• W2014017310 type Work @default.
• W2014017310 sameAs 2014017310 @default.
• W2014017310 citedByCount "339" @default.
• W2014017310 countsByYear W20140173102012 @default.
• W2014017310 countsByYear W20140173102013 @default.
• W2014017310 countsByYear W20140173102014 @default.
• W2014017310 countsByYear W20140173102015 @default.
• W2014017310 countsByYear W20140173102016 @default.
• W2014017310 countsByYear W20140173102017 @default.
• W2014017310 countsByYear W20140173102018 @default.
• W2014017310 countsByYear W20140173102019 @default.
• W2014017310 countsByYear W20140173102020 @default.
• W2014017310 countsByYear W20140173102021 @default.
• W2014017310 countsByYear W20140173102022 @default.
• W2014017310 countsByYear W20140173102023 @default.
• W2014017310 crossrefType "journal-article" @default.
• W2014017310 hasAuthorship W2014017310A5002801126 @default.
• W2014017310 hasAuthorship W2014017310A5004396985 @default.
• W2014017310 hasAuthorship W2014017310A5005368354 @default.
• W2014017310 hasAuthorship W2014017310A5012879670 @default.
• W2014017310 hasAuthorship W2014017310A5032148612 @default.
• W2014017310 hasAuthorship W2014017310A5042070411 @default.
• W2014017310 hasAuthorship W2014017310A5070645953 @default.
• W2014017310 hasBestOaLocation W20140173101 @default.
• W2014017310 hasConcept C101762097 @default.
• W2014017310 hasConcept C104317684 @default.
• W2014017310 hasConcept C1292079 @default.
• W2014017310 hasConcept C138885662 @default.
• W2014017310 hasConcept C139124968 @default.
• W2014017310 hasConcept C150194340 @default.
• W2014017310 hasConcept C153911025 @default.
• W2014017310 hasConcept C172768829 @default.
• W2014017310 hasConcept C179926584 @default.

• next