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- W2014017997 abstract "Previous functional MRI studies have shown that parental family history (FH+) of Alzheimer's disease (AD) is associated with preclinical brain differences compared to controls (FH–). In this study, we examine the rate of Whole Brain Volume (WBV) decline in FH+ participants and examine the impact of modifying factors. Over 240 subjects have received baseline scans at time of this submission; 49 have returned for a four-year follow-up. All subjects were imaged with 3T T1W MRI scans and received a comprehensive neuropsychological battery. Two gender and APOEe4 balanced cohorts were scanned: a middle-aged FH+ cohort (N: 35, mean age: 56) and an older preclinical dementia Mild Cognitive Impairment (MCI) and control cohort (N: 6,8; mean age: 73, 71 respectively). Percent change in WBV was calculated using SIENA (FMRIB), and Pearson correlations and independent samples T-tests were performed using SPSS. WBV in cognitively normal FH+ participants declined at an annual rate of .23% (not dependent on genetic status). There was no change in cognition from baseline to follow-up, nor was there a relationship between cognition and brain volume decline. In contrast, level of education was positively correlated with WBV decline (p<.05). Rate of decline was significantly faster in participants with greater levels of education. WBV in MCI subjects declined at an annual rate of .85%, while age-matched controls declined at .50%. This trends towards significance but more participants are needed. Within our returning cohort, the rate of annual brain volume decline was not affected by APOE4 status, but was correlated with education. Our finding supports a similar positive relationship reported by Fotenos et al. (2008) between SES and annual brain volume decline, which has been hypothesized to be a measure of cognitive reserve delaying disease expression. The annual brain volume decline of the FH+ sample (.23%) is similar to published rates for this age range (.2%–.3%), which might suggest that FH has no effect on the rate of decline, but to completely address this a FH- sample is needed." @default.
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- W2014017997 date "2008-07-01" @default.
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- W2014017997 title "P2-028: Rate of whole brain volume decline in a cohort of cognitively normal participants with family history of Alzheimer's disease: A longitudinal study" @default.
- W2014017997 doi "https://doi.org/10.1016/j.jalz.2008.05.1109" @default.
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