Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014019609> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2014019609 endingPage "860" @default.
- W2014019609 startingPage "851" @default.
- W2014019609 abstract "Guinea pig vas deferens responds to externally applied acetylcholine (ACh) or noradrenaline (NA) by a small rapid contraction (phasi phase) and then a large contraction (tonic phase). The phasic phase was not affected by removal of external Ca2+, but tonic phase depended on external Ca2+. At lower temperatures the two components became larger and detectable separately. The tonic phase induced by ACh at low temperature (at 20°C) was greatly depressed by brief treatment with colchicine (0.5 μM – 5 μM), although the tonic phase at high temperature (at 37°C) was not affected. Na-induced contraction (phasic or tonic phase) was not changed by the colchicine-treatment. High K+ (40 mM)-contracture, which in many cases consisted of a single phase and depended on external Ca2+, was also not affected by brief treatment with colchicine. Culture of vas deferens for 3 days in the presence of colchicine, increased the phasic phase of ACh- and NA-induced contractions significantly, but reduced the tonic phase of contractions induced by ACh and NA. Colchicine also reduced high K+-contracture, the decrease depending on the period of culture with colchicine. Organ culture with colchicine did not affect the amounts of m-ACh and α-Ad receptors or the IC50 value of ACh and NA on 3H-ligand binding. These results suggest that colchicine specifically interacts with some steps in m-ACh and α-Ad receptor-responsor (e.g. ionophore) coupling without affecting the receptor number or affinity of the receptors for agonists. The mechanisms of action of colchicine are discussed in relation to m-ACh and α-Ad receptor functions." @default.
- W2014019609 created "2016-06-24" @default.
- W2014019609 creator A5034882455 @default.
- W2014019609 creator A5038489256 @default.
- W2014019609 creator A5046520123 @default.
- W2014019609 creator A5046748617 @default.
- W2014019609 creator A5048362422 @default.
- W2014019609 date "1981-02-01" @default.
- W2014019609 modified "2023-09-27" @default.
- W2014019609 title "Action of colchicine on cholinergic and adrenergic mechanisms in guinea pig vas deferens" @default.
- W2014019609 cites W1512770672 @default.
- W2014019609 cites W1772857359 @default.
- W2014019609 cites W1964857270 @default.
- W2014019609 cites W1968381830 @default.
- W2014019609 cites W1972577327 @default.
- W2014019609 cites W1972688916 @default.
- W2014019609 cites W1973973669 @default.
- W2014019609 cites W1977375676 @default.
- W2014019609 cites W1990810062 @default.
- W2014019609 cites W2006868908 @default.
- W2014019609 cites W2007871111 @default.
- W2014019609 cites W2014111496 @default.
- W2014019609 cites W2043507048 @default.
- W2014019609 cites W2067009284 @default.
- W2014019609 cites W2071365846 @default.
- W2014019609 cites W2073684748 @default.
- W2014019609 cites W2076041933 @default.
- W2014019609 cites W2076952920 @default.
- W2014019609 cites W2082002150 @default.
- W2014019609 cites W2087022827 @default.
- W2014019609 cites W2125213900 @default.
- W2014019609 doi "https://doi.org/10.1016/0024-3205(81)90046-1" @default.
- W2014019609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6261064" @default.
- W2014019609 hasPublicationYear "1981" @default.
- W2014019609 type Work @default.
- W2014019609 sameAs 2014019609 @default.
- W2014019609 citedByCount "7" @default.
- W2014019609 crossrefType "journal-article" @default.
- W2014019609 hasAuthorship W2014019609A5034882455 @default.
- W2014019609 hasAuthorship W2014019609A5038489256 @default.
- W2014019609 hasAuthorship W2014019609A5046520123 @default.
- W2014019609 hasAuthorship W2014019609A5046748617 @default.
- W2014019609 hasAuthorship W2014019609A5048362422 @default.
- W2014019609 hasConcept C126322002 @default.
- W2014019609 hasConcept C127573956 @default.
- W2014019609 hasConcept C134018914 @default.
- W2014019609 hasConcept C163415756 @default.
- W2014019609 hasConcept C170493617 @default.
- W2014019609 hasConcept C185592680 @default.
- W2014019609 hasConcept C22885893 @default.
- W2014019609 hasConcept C2775910092 @default.
- W2014019609 hasConcept C2776636253 @default.
- W2014019609 hasConcept C2778210472 @default.
- W2014019609 hasConcept C71924100 @default.
- W2014019609 hasConcept C80161118 @default.
- W2014019609 hasConcept C86803240 @default.
- W2014019609 hasConceptScore W2014019609C126322002 @default.
- W2014019609 hasConceptScore W2014019609C127573956 @default.
- W2014019609 hasConceptScore W2014019609C134018914 @default.
- W2014019609 hasConceptScore W2014019609C163415756 @default.
- W2014019609 hasConceptScore W2014019609C170493617 @default.
- W2014019609 hasConceptScore W2014019609C185592680 @default.
- W2014019609 hasConceptScore W2014019609C22885893 @default.
- W2014019609 hasConceptScore W2014019609C2775910092 @default.
- W2014019609 hasConceptScore W2014019609C2776636253 @default.
- W2014019609 hasConceptScore W2014019609C2778210472 @default.
- W2014019609 hasConceptScore W2014019609C71924100 @default.
- W2014019609 hasConceptScore W2014019609C80161118 @default.
- W2014019609 hasConceptScore W2014019609C86803240 @default.
- W2014019609 hasIssue "8" @default.
- W2014019609 hasLocation W20140196091 @default.
- W2014019609 hasLocation W20140196092 @default.
- W2014019609 hasOpenAccess W2014019609 @default.
- W2014019609 hasPrimaryLocation W20140196091 @default.
- W2014019609 hasRelatedWork W1993141839 @default.
- W2014019609 hasRelatedWork W1993142192 @default.
- W2014019609 hasRelatedWork W2033472167 @default.
- W2014019609 hasRelatedWork W2034583712 @default.
- W2014019609 hasRelatedWork W2046226634 @default.
- W2014019609 hasRelatedWork W2063619316 @default.
- W2014019609 hasRelatedWork W2107563524 @default.
- W2014019609 hasRelatedWork W2169225653 @default.
- W2014019609 hasRelatedWork W2414846389 @default.
- W2014019609 hasRelatedWork W3098936795 @default.
- W2014019609 hasVolume "28" @default.
- W2014019609 isParatext "false" @default.
- W2014019609 isRetracted "false" @default.
- W2014019609 magId "2014019609" @default.
- W2014019609 workType "article" @default.