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- W201401976 abstract "This review demonstrates the importance of mathematical modelling in an assessment of myocardial function, and addresses the following questions: (1)What is the effect of shape on the diastolic LV pressure-volume relationship and on the quantitation of myocardial stiffness-stress relations?(2)What are the important determinants of chamber stiffness and what are the mechanisms involved in the shifts of the P-V curves following certain drug interventions?(3)How do infarcts affect diastolic and systolic function? and(4)How may contractile reserve be assessed?Employing the theory of elasticity, these models demonstrate that; (a) in the absence of segmental disease, diastolic P-V and stiffness-stress relations are little affected by LV shape, (b) intrinsic chamber stiffness is complexly related to myocardial elasticity, cavity size, volume/mass ratio and the coronary blood volume, and external pressures are the dominant factors causing dramatic shifts in the P-V relations following certain drug interventions, (c) normal myocardium is restrained by neighbouring infarcts which disrupt border zone contraction patterns. Furthermore, there is a progressive degradation of cardiac performance with increasing infarct size, (d) end systolic P-V relations and end diastolic P-V relations determine the critical EDV at which maximum stroke volume occurs." @default.
- W201401976 created "2016-06-24" @default.
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- W201401976 date "1985-01-01" @default.
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- W201401976 title "The role of mathematical models in an assessment of myocardial function" @default.
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- W201401976 doi "https://doi.org/10.1007/978-94-009-4992-8_4" @default.
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