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- W2014020481 abstract "Imprinted genes harbor discrete regions which are differentially methylated in gametes; usually the final differential methylation patterns in adults are established during embryogenesis through modifications of the initial methylation patterns in gametes. Previous reports have shown that a 200-bp region termed region II within the CpG island of the mouse imprinted U2afbp-rs gene is methylated in oocytes but not in sperm, suggesting that this region is a center for the propagation of methylated CpGs on the maternal allele and is also a candidate for an imprinting control element. To determine whether region II is required for the imprinted methylation of this gene at the endogenous locus, we generated mice carrying a deletion of this region. We herein show that parental methylation differences still exist in the CpG island on the region II-deleted allele. These findings suggest that region II is dispensable for the imprinted methylation of the U2afbp-rs gene." @default.
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- W2014020481 date "2000-02-01" @default.
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- W2014020481 title "The Oocyte-Specific Methylated Region of the U2afbp-rs/U2af1-rs1 Gene Is Dispensable for Its Imprinted Methylation" @default.
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- W2014020481 doi "https://doi.org/10.1006/bbrc.2000.2189" @default.
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