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• W2014021851 abstract "Optically active (1S,2R)-NCL-1 and (1R,2S)-NCL-1 were synthesized and evaluated for their lysine-specific demethylase 1 inhibitory activity and cell growth inhibitory activity. In enzyme assays, the (1S,2R)-isomer was approximately four times more potent than the (1R,2S)-isomer. In cell growth inhibition assays, the two isomers showed similar activity in HEK293 cells and SH-SY5Y cells, whereas the (1S,2R)-isomer showed approximately four times more potent activity than the (1R,2S)-isomer in HeLa cells." @default.
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• W2014021851 date "2011-06-01" @default.
• W2014021851 modified "2023-10-18" @default.
• W2014021851 title "Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor" @default.
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• W2014021851 doi "https://doi.org/10.1016/j.bmc.2010.12.024" @default.
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