Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014023489> ?p ?o ?g. }
- W2014023489 endingPage "641" @default.
- W2014023489 startingPage "629" @default.
- W2014023489 abstract "Glutaredoxins (Grx) represent a large family of glutathione (GSH)-dependent oxidoreductases that catalyse the reduction of disulfides or glutathione mixed disulfide. Grx domains from pathogenic bacteria and plant Grxs have been recently reported to target specific peroxiredoxins (Prxs). The specificity that triggers the interaction between Grx and Prx is poorly understood and is only based on the structure of Haemophilus influenzae Prx–Grx hybrid (hyPrx5). We report here an NMR study of the Populus tremula Grx C4 that targets a P. tremula D-type II Prx. We show that Grx C4 specifically self-associates in a monomer–dimer equilibrium with an apparent Kd of ca 2.6 mM. Grx C4 homodimer was docked under experimental restraints. The results reveal a novel Grx–Grx interface that is unrelated to the hyPrx5 Grx–Grx dimer interface. Chemical-shift perturbations and 15N spin-relaxation measurements show that the auto-association surface comprises both the active site and the GSH binding site. Reduced GSH is demonstrated to bind reduced Grx with a Kd of ca 8.6 mM. The potential biological significance of the new Grx–Grx interaction interface is discussed." @default.
- W2014023489 created "2016-06-24" @default.
- W2014023489 creator A5033924169 @default.
- W2014023489 creator A5034559960 @default.
- W2014023489 creator A5036247960 @default.
- W2014023489 creator A5051010750 @default.
- W2014023489 creator A5076133005 @default.
- W2014023489 creator A5086171605 @default.
- W2014023489 date "2005-10-01" @default.
- W2014023489 modified "2023-10-18" @default.
- W2014023489 title "NMR Reveals a Novel Glutaredoxin–Glutaredoxin Interaction Interface" @default.
- W2014023489 cites W1507082667 @default.
- W2014023489 cites W1967253478 @default.
- W2014023489 cites W1970714977 @default.
- W2014023489 cites W1971317954 @default.
- W2014023489 cites W1972517613 @default.
- W2014023489 cites W1973948721 @default.
- W2014023489 cites W1974601783 @default.
- W2014023489 cites W1983850019 @default.
- W2014023489 cites W1993124282 @default.
- W2014023489 cites W1994205496 @default.
- W2014023489 cites W1998931405 @default.
- W2014023489 cites W2002794726 @default.
- W2014023489 cites W2003954743 @default.
- W2014023489 cites W2005076398 @default.
- W2014023489 cites W2008554228 @default.
- W2014023489 cites W2010903696 @default.
- W2014023489 cites W2015335905 @default.
- W2014023489 cites W2017061009 @default.
- W2014023489 cites W2029192276 @default.
- W2014023489 cites W2030188579 @default.
- W2014023489 cites W2031170611 @default.
- W2014023489 cites W2035799037 @default.
- W2014023489 cites W2044726248 @default.
- W2014023489 cites W2045511006 @default.
- W2014023489 cites W2045648308 @default.
- W2014023489 cites W2046578731 @default.
- W2014023489 cites W2055957948 @default.
- W2014023489 cites W2056842885 @default.
- W2014023489 cites W2062517296 @default.
- W2014023489 cites W2065283382 @default.
- W2014023489 cites W2070615094 @default.
- W2014023489 cites W2070693463 @default.
- W2014023489 cites W2071380046 @default.
- W2014023489 cites W2071845915 @default.
- W2014023489 cites W2076735493 @default.
- W2014023489 cites W2081097951 @default.
- W2014023489 cites W2081912151 @default.
- W2014023489 cites W2082176639 @default.
- W2014023489 cites W2084353662 @default.
- W2014023489 cites W2091711702 @default.
- W2014023489 cites W2093392768 @default.
- W2014023489 cites W2100227713 @default.
- W2014023489 cites W2107355417 @default.
- W2014023489 cites W2118940991 @default.
- W2014023489 cites W2119684298 @default.
- W2014023489 cites W212221849 @default.
- W2014023489 cites W2123226016 @default.
- W2014023489 cites W2129879061 @default.
- W2014023489 cites W2153983456 @default.
- W2014023489 cites W2158496331 @default.
- W2014023489 cites W2162233091 @default.
- W2014023489 cites W2166739931 @default.
- W2014023489 cites W2169821755 @default.
- W2014023489 cites W2410930290 @default.
- W2014023489 cites W257723696 @default.
- W2014023489 cites W286267401 @default.
- W2014023489 doi "https://doi.org/10.1016/j.jmb.2005.08.035" @default.
- W2014023489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16181638" @default.
- W2014023489 hasPublicationYear "2005" @default.
- W2014023489 type Work @default.
- W2014023489 sameAs 2014023489 @default.
- W2014023489 citedByCount "24" @default.
- W2014023489 countsByYear W20140234892012 @default.
- W2014023489 countsByYear W20140234892013 @default.
- W2014023489 countsByYear W20140234892014 @default.
- W2014023489 countsByYear W20140234892016 @default.
- W2014023489 countsByYear W20140234892017 @default.
- W2014023489 countsByYear W20140234892021 @default.
- W2014023489 crossrefType "journal-article" @default.
- W2014023489 hasAuthorship W2014023489A5033924169 @default.
- W2014023489 hasAuthorship W2014023489A5034559960 @default.
- W2014023489 hasAuthorship W2014023489A5036247960 @default.
- W2014023489 hasAuthorship W2014023489A5051010750 @default.
- W2014023489 hasAuthorship W2014023489A5076133005 @default.
- W2014023489 hasAuthorship W2014023489A5086171605 @default.
- W2014023489 hasConcept C125619963 @default.
- W2014023489 hasConcept C178790620 @default.
- W2014023489 hasConcept C181199279 @default.
- W2014023489 hasConcept C185592680 @default.
- W2014023489 hasConcept C2779546866 @default.
- W2014023489 hasConcept C538909803 @default.
- W2014023489 hasConcept C55493867 @default.
- W2014023489 hasConcept C8010536 @default.
- W2014023489 hasConceptScore W2014023489C125619963 @default.
- W2014023489 hasConceptScore W2014023489C178790620 @default.
- W2014023489 hasConceptScore W2014023489C181199279 @default.
- W2014023489 hasConceptScore W2014023489C185592680 @default.