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- W2014023691 abstract "Abstract Concentration-effect curves to phenylephrine are shifted to the right in the presence of endothelium in rat aorta while responses to clonidine are practically abolished. Analysis of the concentration-effect curves showed that the effect of endothelium could possibly be explained by a reduction in relative intrinsic efficacy of the two agonists by between 3.5- and 6-fold. Published observations on the modulatory effects of agonist-induced contractions by endothelium in the rat aorta tend to support this explanation. It is further concluded that this reduction in efficacy could be related to the basal release of an endothelium-derived substance and that changes in tissue contractility in the presence of endothelium cannot necessarily be taken as evidence for a stimulated liberation of endothelium-derived products by agonists." @default.
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- W2014023691 date "1986-03-01" @default.
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- W2014023691 title "Role of efficacy in the assessment of the actions of α-adrenoceptor agonists in rat aorta with endothelium" @default.
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- W2014023691 doi "https://doi.org/10.1111/j.2042-7158.1986.tb04545.x" @default.
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