FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014027124> ?p ?o ?g. }

• W2014027124 abstract "In mammals, hypoxia causes facilitated erythropoiesis that requires increased iron availability with established links between oxygen and iron in regulation of the transcription factor hypoxia-inducible factor. Therefore, cellular responses to hypoxia and iron starvation are linked in mammals and are host conditions that pathogens encounter during infection. In human pathogenic fungi, molecular mechanisms underlying hypoxia adaptation and iron homeostasis have been investigated. However, the interconnected regulation of hypoxia adaptation and iron homeostasis remains to be fully elucidated. This review discusses the potential transcriptional regulatory links between hypoxia adaptation and iron homeostasis in human pathogenic fungi. Transcriptome analyses demonstrate that core regulators of hypoxia adaptation and iron homeostasis are involved in regulation of several common genes responsible for iron acquisition and ergosterol biosynthesis. Importantly, iron starvation increases susceptibility of fungal cells to antifungal drugs and decreased levels of ergosterol, while key hypoxia regulators are also involved in responses to antifungal drugs and mediating ergosterol levels. We suggest that pathogenic fungi have developed a coordinated regulatory system in response to hypoxia and iron starvation through (i) regulation of expression of hypoxia-responsive and iron-responsive genes via cross-linked key regulators, and/or (ii) regulation of factors involved in ergosterol biosynthesis. Thus, both oxygen and iron availability are intimately tied with fungal virulence and responses to existing therapeutics and further elucidation of their interrelationship should have significant clinical implications." @default.
• W2014027124 created "2016-06-24" @default.
• W2014027124 creator A5060027924 @default.
• W2014027124 creator A5068062624 @default.
• W2014027124 creator A5074572683 @default.
• W2014027124 date "2012-01-01" @default.
• W2014027124 modified "2023-09-25" @default.
• W2014027124 title "Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi" @default.
• W2014027124 cites W1579395475 @default.
• W2014027124 cites W1705604029 @default.
• W2014027124 cites W1949177183 @default.
• W2014027124 cites W1953566431 @default.
• W2014027124 cites W1957500099 @default.
• W2014027124 cites W1965114271 @default.
• W2014027124 cites W1965841590 @default.
• W2014027124 cites W1966022765 @default.
• W2014027124 cites W1969289841 @default.
• W2014027124 cites W1970548725 @default.
• W2014027124 cites W1970761589 @default.
• W2014027124 cites W1975390013 @default.
• W2014027124 cites W1977913702 @default.
• W2014027124 cites W1982988838 @default.
• W2014027124 cites W1985056953 @default.
• W2014027124 cites W1985245427 @default.
• W2014027124 cites W1985692664 @default.
• W2014027124 cites W1990281333 @default.
• W2014027124 cites W1991047577 @default.
• W2014027124 cites W1996612655 @default.
• W2014027124 cites W1997977268 @default.
• W2014027124 cites W2005363381 @default.
• W2014027124 cites W2011141565 @default.
• W2014027124 cites W2011168394 @default.
• W2014027124 cites W2013591045 @default.
• W2014027124 cites W2021497905 @default.
• W2014027124 cites W2024601786 @default.
• W2014027124 cites W2041611856 @default.
• W2014027124 cites W2047119299 @default.
• W2014027124 cites W2059526796 @default.
• W2014027124 cites W2072839085 @default.
• W2014027124 cites W2074972577 @default.
• W2014027124 cites W2082915790 @default.
• W2014027124 cites W2083385012 @default.
• W2014027124 cites W2104346191 @default.
• W2014027124 cites W2105317955 @default.
• W2014027124 cites W2114012147 @default.
• W2014027124 cites W2116991069 @default.
• W2014027124 cites W2121738871 @default.
• W2014027124 cites W2125076437 @default.
• W2014027124 cites W2138907159 @default.
• W2014027124 cites W2140936126 @default.
• W2014027124 cites W2141159242 @default.
• W2014027124 cites W2143178270 @default.
• W2014027124 cites W2143449612 @default.
• W2014027124 cites W2146523084 @default.
• W2014027124 cites W2147323333 @default.
• W2014027124 cites W2150543962 @default.
• W2014027124 cites W2151067242 @default.
• W2014027124 cites W2158645874 @default.
• W2014027124 cites W2160849328 @default.
• W2014027124 cites W2166155677 @default.
• W2014027124 cites W2166751413 @default.
• W2014027124 cites W2325700356 @default.
• W2014027124 cites W99389354 @default.
• W2014027124 doi "https://doi.org/10.3389/fmicb.2012.00381" @default.
• W2014027124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3490150" @default.
• W2014027124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23133438" @default.
• W2014027124 hasPublicationYear "2012" @default.
• W2014027124 type Work @default.
• W2014027124 sameAs 2014027124 @default.
• W2014027124 citedByCount "25" @default.
• W2014027124 countsByYear W20140271242013 @default.
• W2014027124 countsByYear W20140271242014 @default.
• W2014027124 countsByYear W20140271242015 @default.
• W2014027124 countsByYear W20140271242016 @default.
• W2014027124 countsByYear W20140271242017 @default.
• W2014027124 countsByYear W20140271242018 @default.
• W2014027124 countsByYear W20140271242019 @default.
• W2014027124 countsByYear W20140271242020 @default.
• W2014027124 countsByYear W20140271242022 @default.
• W2014027124 countsByYear W20140271242023 @default.
• W2014027124 crossrefType "journal-article" @default.
• W2014027124 hasAuthorship W2014027124A5060027924 @default.
• W2014027124 hasAuthorship W2014027124A5068062624 @default.
• W2014027124 hasAuthorship W2014027124A5074572683 @default.
• W2014027124 hasBestOaLocation W20140271241 @default.
• W2014027124 hasConcept C104317684 @default.
• W2014027124 hasConcept C139807058 @default.
• W2014027124 hasConcept C150194340 @default.
• W2014027124 hasConcept C156902634 @default.
• W2014027124 hasConcept C160450060 @default.
• W2014027124 hasConcept C162317418 @default.
• W2014027124 hasConcept C165864922 @default.
• W2014027124 hasConcept C169760540 @default.
• W2014027124 hasConcept C178790620 @default.
• W2014027124 hasConcept C185592680 @default.
• W2014027124 hasConcept C2777910421 @default.
• W2014027124 hasConcept C540031477 @default.
• W2014027124 hasConcept C55493867 @default.
• W2014027124 hasConcept C63645605 @default.
• W2014027124 hasConcept C7836513 @default.

• next