Matches in SemOpenAlex for { <https://semopenalex.org/work/W201403004> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W201403004 endingPage "631" @default.
- W201403004 startingPage "625" @default.
- W201403004 abstract "In order to carry out their biological functions, most polypeptide chains must fold into stable three-dimensional structures, for it is the precise spatial distribution of chemical groups within a protein that gives the molecule its ability to interact specifically with other molecules and, in the case of an enzyme, catalyze a chemical reaction. In many cases, individual polypeptide chains must also assemble into larger structures containing additional proteins or nucleic acids. The folding of many proteins is reversible, so that the native structure can be disrupted by a change in temperature or addition of a chemical denaturant, and the unfolded protein can then be induced to refold and assemble by returning it to physiological conditions. Experiments of this type demonstrate that the information specifying the native structure of a protein resides in its amino acid sequence, and in vitro studies have provided important insights into the energetic factors that drive folding and assembly and the kinetic mechanisms of these processes. Folding in vivo is often facilitated by transient interactions with other proteins, molecular chaperones. Folding may also compete with the formation of aberrant aggregates in vivo, sometimes leading to pathological conditions such as amyloid diseases." @default.
- W201403004 created "2016-06-24" @default.
- W201403004 creator A5032111372 @default.
- W201403004 date "2013-01-01" @default.
- W201403004 modified "2023-10-16" @default.
- W201403004 title "Protein Folding and Assembly" @default.
- W201403004 cites W1588812136 @default.
- W201403004 cites W1965488063 @default.
- W201403004 cites W2012541956 @default.
- W201403004 cites W2016980705 @default.
- W201403004 cites W2054639560 @default.
- W201403004 cites W2069384750 @default.
- W201403004 cites W2078010704 @default.
- W201403004 cites W2129020329 @default.
- W201403004 cites W2144893180 @default.
- W201403004 cites W2157696775 @default.
- W201403004 cites W2165186407 @default.
- W201403004 doi "https://doi.org/10.1016/b978-0-12-378630-2.00064-5" @default.
- W201403004 hasPublicationYear "2013" @default.
- W201403004 type Work @default.
- W201403004 sameAs 201403004 @default.
- W201403004 citedByCount "1" @default.
- W201403004 countsByYear W2014030042014 @default.
- W201403004 crossrefType "book-chapter" @default.
- W201403004 hasAuthorship W201403004A5032111372 @default.
- W201403004 hasConcept C119599485 @default.
- W201403004 hasConcept C12554922 @default.
- W201403004 hasConcept C127413603 @default.
- W201403004 hasConcept C185592680 @default.
- W201403004 hasConcept C19472624 @default.
- W201403004 hasConcept C204328495 @default.
- W201403004 hasConcept C24107716 @default.
- W201403004 hasConcept C2776545253 @default.
- W201403004 hasConcept C515207424 @default.
- W201403004 hasConcept C55493867 @default.
- W201403004 hasConcept C86803240 @default.
- W201403004 hasConceptScore W201403004C119599485 @default.
- W201403004 hasConceptScore W201403004C12554922 @default.
- W201403004 hasConceptScore W201403004C127413603 @default.
- W201403004 hasConceptScore W201403004C185592680 @default.
- W201403004 hasConceptScore W201403004C19472624 @default.
- W201403004 hasConceptScore W201403004C204328495 @default.
- W201403004 hasConceptScore W201403004C24107716 @default.
- W201403004 hasConceptScore W201403004C2776545253 @default.
- W201403004 hasConceptScore W201403004C515207424 @default.
- W201403004 hasConceptScore W201403004C55493867 @default.
- W201403004 hasConceptScore W201403004C86803240 @default.
- W201403004 hasLocation W2014030041 @default.
- W201403004 hasOpenAccess W201403004 @default.
- W201403004 hasPrimaryLocation W2014030041 @default.
- W201403004 hasRelatedWork W2011324275 @default.
- W201403004 hasRelatedWork W2016081971 @default.
- W201403004 hasRelatedWork W2043930245 @default.
- W201403004 hasRelatedWork W2058274562 @default.
- W201403004 hasRelatedWork W2061689941 @default.
- W201403004 hasRelatedWork W2068450894 @default.
- W201403004 hasRelatedWork W2093701091 @default.
- W201403004 hasRelatedWork W2095205630 @default.
- W201403004 hasRelatedWork W2113188411 @default.
- W201403004 hasRelatedWork W2279569368 @default.
- W201403004 isParatext "false" @default.
- W201403004 isRetracted "false" @default.
- W201403004 magId "201403004" @default.
- W201403004 workType "book-chapter" @default.