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- W2014034103 abstract "Oxidative stress has been identified as an important contributor to neurodegeneration associated with acute CNS injuries and diseases such as spinal cord injury (SCI), traumatic brain injury (TBI), and ischemic stroke. In this review, we briefly detail the damaging effects of oxidative stress (lipid peroxidation, protein oxidation, etc.) with a particular emphasis on DNA damage. Evidence for DNA damage in acute CNS injuries is presented along with its downstream effects on neuronal viability. In particular, unchecked oxidative DNA damage initiates a series of signaling events (e.g. activation of p53 and PARP-1, cell cycle re-activation) which have been shown to promote neuronal loss following CNS injury. These findings suggest that preventing DNA damage might be an effective way to promote neuronal survival and enhance neurological recovery in these conditions. Finally, we identify the telomere and telomere-associated proteins (e.g. telomerase) as novel therapeutic targets in the treatment of neurodegeneration due to their ability to modulate the neuronal response to both oxidative stress and DNA damage." @default.
- W2014034103 created "2016-06-24" @default.
- W2014034103 creator A5004747770 @default.
- W2014034103 creator A5052300297 @default.
- W2014034103 creator A5058038217 @default.
- W2014034103 creator A5076638736 @default.
- W2014034103 date "2013-04-01" @default.
- W2014034103 modified "2023-09-29" @default.
- W2014034103 title "Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration" @default.
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