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- W2014034588 abstract "(1) Two different and independent modes of inhibition of the Ca2+ pump by Ca2+ can be detected measuring active Ca2+ extrusion from resealed ghosts of human red cells; one requires extracellular and the other requires intracellular Ca2+. (2) Ki for inhibition by extracellular Ca2+ is about 10 mM. (3) Extracellular Mg2+ replaces Ca2+ in inhibiting Ca2+ transport but with an apparent affinity for inhibition about 3-times less than that for Ca2+. (4) Inhibition by external Ca2+ is not affected by Na+ or K+ at both surfaces of the cell membrane, external EGTA, internal Ca2+ or ATP. (5) The apparent affinity for external Ca2+ progressively raises as pH increases. (6) The effects of extracellular Ca2+ and Mg2+ are consistent with the idea that for Ca2+ pumping to proceed, external sites in the pump must be protonated and not occupied by extracellular Ca2+ or Mg2+ (6). Inhibition by intracellular Ca2+ takes place with a Ki of about 1 mM and is independent of external Ca2+. (7). The inhibitory effects of intracellular Ca2+ can be accounted for if Ca2+ and CaATP were competitive inhibitors of the activation of the pump by Mg2+ and MgATP, respectively." @default.
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- W2014034588 title "Two modes of inhibition of the Ca2+ pump in red cells by Ca2+" @default.
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- W2014034588 doi "https://doi.org/10.1016/0005-2736(85)90504-8" @default.
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