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• W2014034794 endingPage "11517" @default.
• W2014034794 startingPage "11510" @default.
• W2014034794 abstract "The Na+-Ca2+ exchanger (NCX1) plays a major role in calcium efflux and therefore in the control and regulation of intracellular calcium in the heart. The exchanger has been shown to be regulated at several levels including transcription. NCX1 mRNA levels are up-regulated in both cardiac hypertrophy and failure. In this work, the 5′-end of the ncx1 gene has been cloned to study the mechanisms that mediate hypertrophic stimulation and cardiac expression. The feline ncx1 gene has three exons that encode 5′-untranslated sequences that are under the control of three tissue-specific promoters. The cardiac promoter drives expression in cardiocytes, but not in mouse L cells. Although it contains at least one enhancer (−2000 to −1250 base pairs (bp)) and one or more negative elements (−1250 to −250 bp), a minimum promoter (−250 to +200 bp) is sufficient for cardiac expression and α-adrenergic stimulation. The Na+-Ca2+ exchanger (NCX1) plays a major role in calcium efflux and therefore in the control and regulation of intracellular calcium in the heart. The exchanger has been shown to be regulated at several levels including transcription. NCX1 mRNA levels are up-regulated in both cardiac hypertrophy and failure. In this work, the 5′-end of the ncx1 gene has been cloned to study the mechanisms that mediate hypertrophic stimulation and cardiac expression. The feline ncx1 gene has three exons that encode 5′-untranslated sequences that are under the control of three tissue-specific promoters. The cardiac promoter drives expression in cardiocytes, but not in mouse L cells. Although it contains at least one enhancer (−2000 to −1250 base pairs (bp)) and one or more negative elements (−1250 to −250 bp), a minimum promoter (−250 to +200 bp) is sufficient for cardiac expression and α-adrenergic stimulation." @default.
• W2014034794 created "2016-06-24" @default.
• W2014034794 creator A5013992427 @default.
• W2014034794 creator A5035327717 @default.
• W2014034794 creator A5048962929 @default.
• W2014034794 creator A5061323145 @default.
• W2014034794 date "1997-04-01" @default.
• W2014034794 modified "2023-10-18" @default.
• W2014034794 title "Cloning of Cardiac, Kidney, and Brain Promoters of the Feline ncx1 Gene" @default.
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• W2014034794 doi "https://doi.org/10.1074/jbc.272.17.11510" @default.
• W2014034794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9111065" @default.
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