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- W2014036536 abstract "A simple, selective, and stability indicating spectroscopic method has been selected and validated for the assay of ceftriaxone sodium in the powder for injection dosage forms. Proposed method is based on the measurement of absorbance of ceftriaxone sodium in aqueous medium at 241 nm. The method obeys Beer’s law in the range of 5–50 μ g/mL with correlation coefficient of 0.9983. Apparent molar absorptivity and Sandell’s sensitivity were found to be <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn>2.046</mml:mn><mml:mo>×</mml:mo><mml:msup><mml:mrow><mml:mn>10</mml:mn></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msup></mml:math> L mol −1 cm −1 and 0.02732 μ g/cm 2 /0.001 absorbance units. This study indicated that ceftriaxone sodium was degraded in acid medium and also underwent oxidative degradation. Percent relative standard deviation associated with all the validation parameters was less than 2, showing compliance with acceptance criteria of Q2 (R1), International Conference on Harmonization (2005) guidelines. Then the proposed method was successfully applied to the determination of ceftriaxone sodium in sterile preparation and results were comparable with reported methods." @default.
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- W2014036536 date "2014-08-24" @default.
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- W2014036536 title "Development and Validation of Stability Indicating Spectroscopic Method for Content Analysis of Ceftriaxone Sodium in Pharmaceuticals" @default.
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- W2014036536 doi "https://doi.org/10.1155/2014/278173" @default.
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