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- W2014036544 abstract "The success of radiotherapy depends on the total radiation dose, which is limited by the tolerance of surrounding normal tissues. Since there is substantial variation among patients in normal-tissue radiosensitivity, we have tested the hypothesis that in-vitro cellular radiosensitivity is correlated with in-vivo normal-tissue responses. We exposed skin fibroblast cell lines from six radiation-treated patients to various doses of radiation and measured the proportions surviving. There was a strong relation between fibroblast sensitivity in vitro and normal-tissue reactions, especially acute effects. Assessment of radiosensitivity could lead to improved tumour cure rates by enabling radiation doses to be tailored to the individual." @default.
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- W2014036544 date "1992-06-01" @default.
- W2014036544 modified "2023-09-25" @default.
- W2014036544 title "Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity" @default.
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- W2014036544 doi "https://doi.org/10.1016/0140-6736(92)91833-t" @default.
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