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- W2014037182 endingPage "18" @default.
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- W2014037182 abstract "1alpha,25-Dihydroxyvitamin D3 (1,25(OH)2D3) alters the proliferation of neuroblastoma cells in culture in part via a nerve growth factor (NGF)-mediated pathway. This suggests that factors other than NGF also play a role in the growth arrest induced by 1,25(OH)2D3. To more fully characterize the effect of 1,25(OH)2D3 on neuroblastoma cells, we treated the cells with 10(-8) M 1,25(OH)2D3 and examined the cells for changes in the expression of N-myc, c-myc, transforming growth factor-beta2 (TGF-beta2), and protein kinase C (PKC) activity. Our results show that 1,25(OH)2D3 causes a decrease in the expression of N-myc and c-myc, as well as a two-fold increase in total PKC activity and a dose-dependent increase in TGF-beta2 expression. These results show that 1,25(OH)2D3 regulates the expression of growth-regulatory factors other than NGF in neuroblastoma cells and that 1,25(OH)2D3 influences the growth of neural cells via multiple growth regulatory pathways." @default.
- W2014037182 created "2016-06-24" @default.
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- W2014037182 date "1997-06-01" @default.
- W2014037182 modified "2023-10-12" @default.
- W2014037182 title "1,25-Dihydroxyvitamin D3Regulates the Expression of N-myc, c-myc, Protein Kinase C, and Transforming Growth Factor-β2 in Neuroblastoma Cells" @default.
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- W2014037182 doi "https://doi.org/10.1006/bbrc.1997.6718" @default.
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