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• W2014037900 abstract "The cells with mammary repopulating capability can achieve mammary gland morphogenesis in a suitable cellular microenvironment. Using cell surface markers of CD24 , CD29 and CD49f, mouse mammary repopulating unit (MRU) has been identified in adult mammary epithelium and late embryonic mammary bud epithelium. However, embryonic MRU remains to be fully characterized at earlier mammary anlagen stage. Here we isolated discrete populations of E14.5 mouse mammary anlagen cells. Only Lin − CD24 med CD29 + cell population was predicted as E14.5 MRU by examining their capacities of forming mammosphere and repopulating cleared mammary fat pad in vivo. However, when we characterized gene expressions of this E14.5 cell population by comparing with adult mouse MRU (Lin − CD24 + CD29 hi ), the gene profiling of these two cell populations exhibited great differences. Real-time PCR and immunostaining assays uncovered that E14.5 Lin − CD24 med CD29 + cell population was a heterogeneous stroma-enriched cell population. Then, limiting dilutions and single-cell assays also confirmed that E14.5 Lin − CD24 med CD29 + cell population possessed low proportion of stem cells. In summary, heterogeneous Lin − CD24 med CD29 + cell population exhibited mammary repopulating ability in E14.5 mammary anlagen, implying that only suitable mammary stroma could enable mammary gland morphogenesis, which relied on the interaction between rare stem cells and microenvironment. • We isolated three E14.5 mouse mammary anlagen cell populations using CD24 and CD29. • Lin − CD24 med CD29 + cell population can repopulate cleared mammary fat pad in vivo. • We characterized gene expressions of E14.5 mouse Lin − CD24 med CD29 + cell population. • E14.5 mouse Lin − CD24 med CD29 + cell population was a heterogeneous cell population. • Characterization of E14.5 Lin − CD24 med CD29 + cells reveals essential mammary stroma." @default.
• W2014037900 created "2016-06-24" @default.
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• W2014037900 date "2014-09-01" @default.
• W2014037900 modified "2023-09-23" @default.
• W2014037900 title "A mammary repopulating cell population characterized in mammary anlagen reveals essential mammary stroma for morphogenesis" @default.
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• W2014037900 doi "https://doi.org/10.1016/j.yexcr.2014.06.008" @default.
• W2014037900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24954407" @default.
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