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- W2014039378 abstract "1. Hydroxyzine, administered intravenously in a dose of 5 mg per kilogram of body weight to the anesthetized dog, effectively antagonized and blocked the spasmogenic actions of acetylcholine, reserpine, 5-hydroxytryptamine (serotonin), histamine, and posterior pituitary extract on the duodenum. 2. This same dose of hydroxyzine given intravenously inhibited and blocked increased uterine activity incident to the administration of both natural and synthetic oxytocin in a dose of 0.5 units per kilogram of body weight in the anesthetized dog. 3. Hydroxyzine in a concentration of 1:100,000 effectively blocked the spasmogenic actions of oxytocin (2.5 units/1000) on the isolated virgin guinea pig uterus. 4. A concentration of 1:100,000 completely inhibited the spasmogenic actions of histamine, 1:5 million; acetylcholine, 1:5 million; and 5-hydroxytryptamine, 1:10 million, on the isolated rabbit or guinea pig ileum. 5. A possible mode of the antispasmodic actions of hydroxyzine has been suggested." @default.
- W2014039378 created "2016-06-24" @default.
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- W2014039378 date "1959-03-01" @default.
- W2014039378 modified "2023-09-23" @default.
- W2014039378 title "Antispasmodic properties of hydroxyzine (atarax)" @default.
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- W2014039378 doi "https://doi.org/10.1016/0041-008x(59)90137-1" @default.
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