FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014043246> ?p ?o ?g. }

• W2014043246 abstract "Abstract Background Parkinson's disease (PD) is the most prevalent incurable neurodegenerative movement disorder. Mutations in LRRK2 are associated with both autosomal dominant familial and sporadic forms of PD. LRRK2 encodes a large putative serine/threonine kinase with GTPase activity. Increased LRRK2 kinase activity plays a critical role in pathogenic LRRK2 mutant-induced neurodegeneration in vitro . Little is known about the physiological function of LRRK2. Results We have recently identified a Drosophila line with a P-element insertion in an ortholog gene of human LRRK2 ( dLRRK ). The insertion results in a truncated Drosophila LRRK variant with N-terminal 1290 amino acids but lacking C-terminal kinase domain. The homozygous mutant fly develops normally with normal life span as well as unchanged number and pattern of dopaminergic neurons. However, dLRRK mutant flies were selectively sensitive to hydrogen peroxide induced stress but not to paraquat, rotenone and β-mercaptoethanol induced stresses. Conclusion Our results indicate that inactivation of d LRRK kinase activity is not essential for fly development and suggest that inhibition of LRRK activity may serve as a potential treatment of PD. However, d LRRK kinase activity likely plays a role in protecting against oxidative stress." @default.
• W2014043246 created "2016-06-24" @default.
• W2014043246 creator A5015894942 @default.
• W2014043246 creator A5035586725 @default.
• W2014043246 creator A5038705827 @default.
• W2014043246 creator A5049361243 @default.
• W2014043246 creator A5066135539 @default.
• W2014043246 creator A5087272196 @default.
• W2014043246 creator A5090934036 @default.
• W2014043246 date "2008-02-08" @default.
• W2014043246 modified "2023-10-15" @default.
• W2014043246 title "Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons" @default.
• W2014043246 cites W1877873625 @default.
• W2014043246 cites W1902946357 @default.
• W2014043246 cites W1970848642 @default.
• W2014043246 cites W1971389338 @default.
• W2014043246 cites W1975722154 @default.
• W2014043246 cites W1980914717 @default.
• W2014043246 cites W1992365739 @default.
• W2014043246 cites W1998924477 @default.
• W2014043246 cites W2006875797 @default.
• W2014043246 cites W2030205108 @default.
• W2014043246 cites W2031053023 @default.
• W2014043246 cites W2031345305 @default.
• W2014043246 cites W2032373330 @default.
• W2014043246 cites W2034415869 @default.
• W2014043246 cites W2049376715 @default.
• W2014043246 cites W2050902269 @default.
• W2014043246 cites W2060112329 @default.
• W2014043246 cites W2062605045 @default.
• W2014043246 cites W2063127941 @default.
• W2014043246 cites W2077822590 @default.
• W2014043246 cites W2100300726 @default.
• W2014043246 cites W2104382960 @default.
• W2014043246 cites W2136388422 @default.
• W2014043246 cites W2137317629 @default.
• W2014043246 cites W2150656456 @default.
• W2014043246 cites W2158778370 @default.
• W2014043246 cites W49996880 @default.
• W2014043246 doi "https://doi.org/10.1186/1750-1326-3-3" @default.
• W2014043246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2276501" @default.
• W2014043246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18257932" @default.
• W2014043246 hasPublicationYear "2008" @default.
• W2014043246 type Work @default.
• W2014043246 sameAs 2014043246 @default.
• W2014043246 citedByCount "107" @default.
• W2014043246 countsByYear W20140432462012 @default.
• W2014043246 countsByYear W20140432462013 @default.
• W2014043246 countsByYear W20140432462014 @default.
• W2014043246 countsByYear W20140432462015 @default.
• W2014043246 countsByYear W20140432462016 @default.
• W2014043246 countsByYear W20140432462017 @default.
• W2014043246 countsByYear W20140432462018 @default.
• W2014043246 countsByYear W20140432462019 @default.
• W2014043246 countsByYear W20140432462020 @default.
• W2014043246 countsByYear W20140432462021 @default.
• W2014043246 countsByYear W20140432462022 @default.
• W2014043246 countsByYear W20140432462023 @default.
• W2014043246 crossrefType "journal-article" @default.
• W2014043246 hasAuthorship W2014043246A5015894942 @default.
• W2014043246 hasAuthorship W2014043246A5035586725 @default.
• W2014043246 hasAuthorship W2014043246A5038705827 @default.
• W2014043246 hasAuthorship W2014043246A5049361243 @default.
• W2014043246 hasAuthorship W2014043246A5066135539 @default.
• W2014043246 hasAuthorship W2014043246A5087272196 @default.
• W2014043246 hasAuthorship W2014043246A5090934036 @default.
• W2014043246 hasBestOaLocation W20140432461 @default.
• W2014043246 hasConcept C104317684 @default.
• W2014043246 hasConcept C124160383 @default.
• W2014043246 hasConcept C126322002 @default.
• W2014043246 hasConcept C137183658 @default.
• W2014043246 hasConcept C137361374 @default.
• W2014043246 hasConcept C143065580 @default.
• W2014043246 hasConcept C169760540 @default.
• W2014043246 hasConcept C184235292 @default.
• W2014043246 hasConcept C2776925932 @default.
• W2014043246 hasConcept C2779134260 @default.
• W2014043246 hasConcept C2779734285 @default.
• W2014043246 hasConcept C2780104201 @default.
• W2014043246 hasConcept C2780427247 @default.
• W2014043246 hasConcept C32619005 @default.
• W2014043246 hasConcept C501734568 @default.
• W2014043246 hasConcept C513476851 @default.
• W2014043246 hasConcept C54355233 @default.
• W2014043246 hasConcept C71924100 @default.
• W2014043246 hasConcept C86803240 @default.
• W2014043246 hasConcept C90934575 @default.
• W2014043246 hasConcept C95444343 @default.
• W2014043246 hasConcept C97029542 @default.
• W2014043246 hasConceptScore W2014043246C104317684 @default.
• W2014043246 hasConceptScore W2014043246C124160383 @default.
• W2014043246 hasConceptScore W2014043246C126322002 @default.
• W2014043246 hasConceptScore W2014043246C137183658 @default.
• W2014043246 hasConceptScore W2014043246C137361374 @default.
• W2014043246 hasConceptScore W2014043246C143065580 @default.
• W2014043246 hasConceptScore W2014043246C169760540 @default.
• W2014043246 hasConceptScore W2014043246C184235292 @default.
• W2014043246 hasConceptScore W2014043246C2776925932 @default.
• W2014043246 hasConceptScore W2014043246C2779134260 @default.
• W2014043246 hasConceptScore W2014043246C2779734285 @default.

• next