FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014044585> ?p ?o ?g. }

• W2014044585 endingPage "201" @default.
• W2014044585 startingPage "196" @default.
• W2014044585 abstract "Efficient electric activation and action potential propagation in the heart largely depends on gap junction (GJ) channels, formed by connexins (Cx) localized at the intercalated discs (IDs). Therefore, fine-tuning and maintenance of GJ in cardiomyocytes is essential for normal heart function. Several mechanisms have been implicated in the regulation of the amount of Cx43 at the plasma membrane. Results from our lab demonstrated that Nedd4-mediated ubiquitination of Cx43 signals internalization and degradation of GJ. However, the pathophysiological relevance of this mechanism has never been addressed before. The main objective of this study was to evaluate the involvement of ubiquitination on GJ remodeling, in the ischemic heart. To address this, we used the rat heart Langendorff model and evaluated the ubiquitination profile of Cx43 and its interaction with Nedd4, after 30 min of no-flow ischemia. By confocal microscopy, we show that ischemia induces extensive co-localization of ubiquitin and Nedd4 with Cx43 localized at IDs. Moreover, by subcellular fractionation and co-immunoprecipitation assays, we demonstrate an increased interaction with Nedd4 and ubiquitination of Cx43 localized at IDs. Altogether, these results suggest that ubiquitin is involved in the remodeling of GJ during myocardial ischemia, which requires the recruitment of Nedd4." @default.
• W2014044585 created "2016-06-24" @default.
• W2014044585 creator A5000612569 @default.
• W2014044585 creator A5015632623 @default.
• W2014044585 creator A5016250397 @default.
• W2014044585 creator A5034517070 @default.
• W2014044585 creator A5045300961 @default.
• W2014044585 creator A5046379632 @default.
• W2014044585 creator A5078930041 @default.
• W2014044585 creator A5091153614 @default.
• W2014044585 date "2015-05-01" @default.
• W2014044585 modified "2023-10-17" @default.
• W2014044585 title "Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs" @default.
• W2014044585 cites W1542751140 @default.
• W2014044585 cites W1965392481 @default.
• W2014044585 cites W1966333337 @default.
• W2014044585 cites W2013411933 @default.
• W2014044585 cites W2043879567 @default.
• W2014044585 cites W2056570135 @default.
• W2014044585 cites W2072030377 @default.
• W2014044585 cites W2111813732 @default.
• W2014044585 cites W2138161732 @default.
• W2014044585 cites W2138885980 @default.
• W2014044585 cites W2147424292 @default.
• W2014044585 cites W2155347215 @default.
• W2014044585 cites W2158368575 @default.
• W2014044585 cites W2171409673 @default.
• W2014044585 cites W2317420320 @default.
• W2014044585 doi "https://doi.org/10.1016/j.biochi.2015.02.020" @default.
• W2014044585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25748165" @default.
• W2014044585 hasPublicationYear "2015" @default.
• W2014044585 type Work @default.
• W2014044585 sameAs 2014044585 @default.
• W2014044585 citedByCount "35" @default.
• W2014044585 countsByYear W20140445852015 @default.
• W2014044585 countsByYear W20140445852016 @default.
• W2014044585 countsByYear W20140445852017 @default.
• W2014044585 countsByYear W20140445852018 @default.
• W2014044585 countsByYear W20140445852019 @default.
• W2014044585 countsByYear W20140445852020 @default.
• W2014044585 countsByYear W20140445852021 @default.
• W2014044585 countsByYear W20140445852022 @default.
• W2014044585 countsByYear W20140445852023 @default.
• W2014044585 crossrefType "journal-article" @default.
• W2014044585 hasAuthorship W2014044585A5000612569 @default.
• W2014044585 hasAuthorship W2014044585A5015632623 @default.
• W2014044585 hasAuthorship W2014044585A5016250397 @default.
• W2014044585 hasAuthorship W2014044585A5034517070 @default.
• W2014044585 hasAuthorship W2014044585A5045300961 @default.
• W2014044585 hasAuthorship W2014044585A5046379632 @default.
• W2014044585 hasAuthorship W2014044585A5078930041 @default.
• W2014044585 hasAuthorship W2014044585A5091153614 @default.
• W2014044585 hasConcept C104317684 @default.
• W2014044585 hasConcept C126322002 @default.
• W2014044585 hasConcept C134459356 @default.
• W2014044585 hasConcept C139770010 @default.
• W2014044585 hasConcept C1491633281 @default.
• W2014044585 hasConcept C158157758 @default.
• W2014044585 hasConcept C185592680 @default.
• W2014044585 hasConcept C25602115 @default.
• W2014044585 hasConcept C2777265272 @default.
• W2014044585 hasConcept C2779178360 @default.
• W2014044585 hasConcept C541997718 @default.
• W2014044585 hasConcept C54355233 @default.
• W2014044585 hasConcept C55493867 @default.
• W2014044585 hasConcept C71829478 @default.
• W2014044585 hasConcept C71924100 @default.
• W2014044585 hasConcept C79879829 @default.
• W2014044585 hasConcept C81885089 @default.
• W2014044585 hasConcept C86803240 @default.
• W2014044585 hasConcept C95444343 @default.
• W2014044585 hasConceptScore W2014044585C104317684 @default.
• W2014044585 hasConceptScore W2014044585C126322002 @default.
• W2014044585 hasConceptScore W2014044585C134459356 @default.
• W2014044585 hasConceptScore W2014044585C139770010 @default.
• W2014044585 hasConceptScore W2014044585C1491633281 @default.
• W2014044585 hasConceptScore W2014044585C158157758 @default.
• W2014044585 hasConceptScore W2014044585C185592680 @default.
• W2014044585 hasConceptScore W2014044585C25602115 @default.
• W2014044585 hasConceptScore W2014044585C2777265272 @default.
• W2014044585 hasConceptScore W2014044585C2779178360 @default.
• W2014044585 hasConceptScore W2014044585C541997718 @default.
• W2014044585 hasConceptScore W2014044585C54355233 @default.
• W2014044585 hasConceptScore W2014044585C55493867 @default.
• W2014044585 hasConceptScore W2014044585C71829478 @default.
• W2014044585 hasConceptScore W2014044585C71924100 @default.
• W2014044585 hasConceptScore W2014044585C79879829 @default.
• W2014044585 hasConceptScore W2014044585C81885089 @default.
• W2014044585 hasConceptScore W2014044585C86803240 @default.
• W2014044585 hasConceptScore W2014044585C95444343 @default.
• W2014044585 hasLocation W20140445851 @default.
• W2014044585 hasLocation W20140445852 @default.
• W2014044585 hasOpenAccess W2014044585 @default.
• W2014044585 hasPrimaryLocation W20140445851 @default.
• W2014044585 hasRelatedWork W1977015834 @default.
• W2014044585 hasRelatedWork W2008523315 @default.
• W2014044585 hasRelatedWork W2014162746 @default.
• W2014044585 hasRelatedWork W2033084145 @default.

• next