Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014051352> ?p ?o ?g. }
- W2014051352 endingPage "e4" @default.
- W2014051352 startingPage "e4" @default.
- W2014051352 abstract "To evaluate the use of a clinical pathway for neonatal sepsis in decisions about initiating and continuing antibiotic treatment.A district hospital primarily served by private pediatricians practicing in a managed care environment. PATIENTS AND LABORATORY TESTS: All infants admitted to the well-baby nursery in 1997-1998 were eligible for this study. Infants born with a variety of risk factors (eg, borderline prematurity, membranes ruptured for over 18 hours, mother positive for group B streptococcus [GBS], and maternal fever) or clinical manifestations suggesting possible infection (either clinical signs or persistent hypoglycemia) were evaluated with white blood cell count, differential, and C-reactive protein (CRP) soon after birth and 12 hours later. Decisions to transfer to the neonatal intensive care unit and to treat with antibiotics were based on abnormal laboratory test results, particularly an increased level of CRP (>1 mg/dL), persistent hypoglycemia, or clinical signs. Discontinuation of antibiotic treatment was primarily based on return to normal of the CRP.Of 8299 live births, 7562 initially went to the well-baby nursery. Evaluation occurred in 1894 (25%) and 425 were transferred to the neonatal intensive care unit. In 162, antibiotics were discontinued within 48 hours. The majority were treated for 3 to 5 days, with only 19 (3 with GBS sepsis) treated for 6 days or more. There were 216 infants transferred because of risk factors and 209 because of clinical findings. Peak CRP primarily determined the duration of antibiotic treatment, with the mean peak CRP rising from 2.8 mg/dL in those treated for 3 days, to 3.8, 4.3, 8.4, 8.9, and 13. 7 mg/dL in those treated for 4, 5, 6, 7, or >7 days, respectively. The mean duration of treatment was 3.1 days. No infant initially treated with antibiotics and discharged when the CRP returned to normal was readmitted within the next month. No infant with normal values on the sepsis screen was readmitted within 1 month with evidence of bacterial infection, but 1 infant with no risk factors was readmitted at 22 days of age with GBS sepsis and meningitis.Using a clinical pathway for neonatal sepsis, which is based primarily on CRP determinations, can minimize antibiotic exposure and shorten hospital stays." @default.
- W2014051352 created "2016-06-24" @default.
- W2014051352 creator A5064277796 @default.
- W2014051352 creator A5084698758 @default.
- W2014051352 date "2000-07-01" @default.
- W2014051352 modified "2023-10-16" @default.
- W2014051352 title "Use of C-Reactive Protein in Minimizing Antibiotic Exposure: Experience With Infants Initially Admitted to a Well-Baby Nursery" @default.
- W2014051352 cites W1554622409 @default.
- W2014051352 cites W1562270853 @default.
- W2014051352 cites W1985139609 @default.
- W2014051352 cites W2003178642 @default.
- W2014051352 cites W2004984874 @default.
- W2014051352 cites W2024639298 @default.
- W2014051352 cites W2026340209 @default.
- W2014051352 cites W2026739125 @default.
- W2014051352 cites W2031511038 @default.
- W2014051352 cites W2043267058 @default.
- W2014051352 cites W2046966488 @default.
- W2014051352 cites W2049796284 @default.
- W2014051352 cites W2051027649 @default.
- W2014051352 cites W2057928036 @default.
- W2014051352 cites W2058109853 @default.
- W2014051352 cites W2071977172 @default.
- W2014051352 cites W2080012182 @default.
- W2014051352 cites W2092849517 @default.
- W2014051352 cites W2095356200 @default.
- W2014051352 cites W2168072356 @default.
- W2014051352 cites W2317184793 @default.
- W2014051352 cites W33489412 @default.
- W2014051352 cites W7652690 @default.
- W2014051352 doi "https://doi.org/10.1542/peds.106.1.e4" @default.
- W2014051352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10878173" @default.
- W2014051352 hasPublicationYear "2000" @default.
- W2014051352 type Work @default.
- W2014051352 sameAs 2014051352 @default.
- W2014051352 citedByCount "115" @default.
- W2014051352 countsByYear W20140513522012 @default.
- W2014051352 countsByYear W20140513522013 @default.
- W2014051352 countsByYear W20140513522014 @default.
- W2014051352 countsByYear W20140513522015 @default.
- W2014051352 countsByYear W20140513522016 @default.
- W2014051352 countsByYear W20140513522017 @default.
- W2014051352 countsByYear W20140513522018 @default.
- W2014051352 countsByYear W20140513522019 @default.
- W2014051352 countsByYear W20140513522020 @default.
- W2014051352 countsByYear W20140513522021 @default.
- W2014051352 countsByYear W20140513522022 @default.
- W2014051352 countsByYear W20140513522023 @default.
- W2014051352 crossrefType "journal-article" @default.
- W2014051352 hasAuthorship W2014051352A5064277796 @default.
- W2014051352 hasAuthorship W2014051352A5084698758 @default.
- W2014051352 hasBestOaLocation W20140513521 @default.
- W2014051352 hasConcept C126322002 @default.
- W2014051352 hasConcept C187212893 @default.
- W2014051352 hasConcept C2775953899 @default.
- W2014051352 hasConcept C2776914184 @default.
- W2014051352 hasConcept C2777091541 @default.
- W2014051352 hasConcept C2778384902 @default.
- W2014051352 hasConcept C2778488018 @default.
- W2014051352 hasConcept C2778715236 @default.
- W2014051352 hasConcept C2779306644 @default.
- W2014051352 hasConcept C2780668416 @default.
- W2014051352 hasConcept C2781195455 @default.
- W2014051352 hasConcept C501593827 @default.
- W2014051352 hasConcept C71924100 @default.
- W2014051352 hasConcept C86803240 @default.
- W2014051352 hasConcept C89423630 @default.
- W2014051352 hasConceptScore W2014051352C126322002 @default.
- W2014051352 hasConceptScore W2014051352C187212893 @default.
- W2014051352 hasConceptScore W2014051352C2775953899 @default.
- W2014051352 hasConceptScore W2014051352C2776914184 @default.
- W2014051352 hasConceptScore W2014051352C2777091541 @default.
- W2014051352 hasConceptScore W2014051352C2778384902 @default.
- W2014051352 hasConceptScore W2014051352C2778488018 @default.
- W2014051352 hasConceptScore W2014051352C2778715236 @default.
- W2014051352 hasConceptScore W2014051352C2779306644 @default.
- W2014051352 hasConceptScore W2014051352C2780668416 @default.
- W2014051352 hasConceptScore W2014051352C2781195455 @default.
- W2014051352 hasConceptScore W2014051352C501593827 @default.
- W2014051352 hasConceptScore W2014051352C71924100 @default.
- W2014051352 hasConceptScore W2014051352C86803240 @default.
- W2014051352 hasConceptScore W2014051352C89423630 @default.
- W2014051352 hasIssue "1" @default.
- W2014051352 hasLocation W20140513521 @default.
- W2014051352 hasLocation W20140513522 @default.
- W2014051352 hasOpenAccess W2014051352 @default.
- W2014051352 hasPrimaryLocation W20140513521 @default.
- W2014051352 hasRelatedWork W1984921258 @default.
- W2014051352 hasRelatedWork W2091458228 @default.
- W2014051352 hasRelatedWork W2115240076 @default.
- W2014051352 hasRelatedWork W2385444830 @default.
- W2014051352 hasRelatedWork W2389304242 @default.
- W2014051352 hasRelatedWork W2399334738 @default.
- W2014051352 hasRelatedWork W2414951211 @default.
- W2014051352 hasRelatedWork W2897413314 @default.
- W2014051352 hasRelatedWork W3030423913 @default.
- W2014051352 hasRelatedWork W3198212963 @default.
- W2014051352 hasVolume "106" @default.