FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014051729> ?p ?o ?g. }

• W2014051729 endingPage "616" @default.
• W2014051729 startingPage "604" @default.
• W2014051729 abstract "The histone deacetylases HDAC1 and HDAC2 are crucial regulators of chromatin structure and gene expression, thereby controlling important developmental processes. In the mouse brain, HDAC1 and HDAC2 exhibit different developmental stage- and lineage-specific expression patterns. To examine the individual contribution of these deacetylases during brain development, we deleted different combinations of Hdac1 and Hdac2 alleles in neural cells. Ablation of Hdac1 or Hdac2 by Nestin-Cre had no obvious consequences on brain development and architecture owing to compensation by the paralog. By contrast, combined deletion of Hdac1 and Hdac2 resulted in impaired chromatin structure, DNA damage, apoptosis and embryonic lethality. To dissect the individual roles of HDAC1 and HDAC2, we expressed single alleles of either Hdac1 or Hdac2 in the absence of the respective paralog in neural cells. The DNA-damage phenotype observed in double knockout brains was prevented by expression of a single allele of either Hdac1 or Hdac2. Strikingly, Hdac1-/-Hdac2+/- brains showed normal development and no obvious phenotype, whereas Hdac1+/-Hdac2-/- mice displayed impaired brain development and perinatal lethality. Hdac1+/-Hdac2-/- neural precursor cells showed reduced proliferation and premature differentiation mediated by overexpression of protein kinase C, delta, which is a direct target of HDAC2. Importantly, chemical inhibition or knockdown of protein kinase C delta was sufficient to rescue the phenotype of neural progenitor cells in vitro. Our data indicate that HDAC1 and HDAC2 have a common function in maintaining proper chromatin structures and show that HDAC2 has a unique role by controlling the fate of neural progenitors during normal brain development." @default.
• W2014051729 created "2016-06-24" @default.
• W2014051729 creator A5008675802 @default.
• W2014051729 creator A5008803187 @default.
• W2014051729 creator A5022062921 @default.
• W2014051729 creator A5024592647 @default.
• W2014051729 creator A5028751448 @default.
• W2014051729 creator A5033137740 @default.
• W2014051729 creator A5036348309 @default.
• W2014051729 creator A5040020133 @default.
• W2014051729 creator A5041146694 @default.
• W2014051729 creator A5049445915 @default.
• W2014051729 creator A5050861407 @default.
• W2014051729 creator A5054505028 @default.
• W2014051729 creator A5059743028 @default.
• W2014051729 creator A5060401985 @default.
• W2014051729 creator A5077535856 @default.
• W2014051729 creator A5081785389 @default.
• W2014051729 creator A5086694842 @default.
• W2014051729 date "2014-02-01" @default.
• W2014051729 modified "2023-10-02" @default.
• W2014051729 title "A single allele of <i>Hdac2</i> but not <i>Hdac1</i> is sufficient for normal mouse brain development in the absence of its paralog" @default.
• W2014051729 cites W1224329310 @default.
• W2014051729 cites W1554882994 @default.
• W2014051729 cites W1761323037 @default.
• W2014051729 cites W1862774878 @default.
• W2014051729 cites W1910848366 @default.
• W2014051729 cites W1963542234 @default.
• W2014051729 cites W1964233786 @default.
• W2014051729 cites W1966135423 @default.
• W2014051729 cites W1966516467 @default.
• W2014051729 cites W1967018540 @default.
• W2014051729 cites W1967064280 @default.
• W2014051729 cites W1967634849 @default.
• W2014051729 cites W1969021739 @default.
• W2014051729 cites W1969386224 @default.
• W2014051729 cites W1970210902 @default.
• W2014051729 cites W1970558626 @default.
• W2014051729 cites W1971615196 @default.
• W2014051729 cites W1975692560 @default.
• W2014051729 cites W1984093745 @default.
• W2014051729 cites W1985856283 @default.
• W2014051729 cites W1987147220 @default.
• W2014051729 cites W1992651146 @default.
• W2014051729 cites W1996277745 @default.
• W2014051729 cites W2004615717 @default.
• W2014051729 cites W2005437050 @default.
• W2014051729 cites W2007139310 @default.
• W2014051729 cites W2008650297 @default.
• W2014051729 cites W2011101614 @default.
• W2014051729 cites W2018801742 @default.
• W2014051729 cites W2022018162 @default.
• W2014051729 cites W2026441085 @default.
• W2014051729 cites W2027259173 @default.
• W2014051729 cites W2027780576 @default.
• W2014051729 cites W2034420564 @default.
• W2014051729 cites W2036700704 @default.
• W2014051729 cites W2037613997 @default.
• W2014051729 cites W2046716387 @default.
• W2014051729 cites W2047809719 @default.
• W2014051729 cites W2051113417 @default.
• W2014051729 cites W2052499568 @default.
• W2014051729 cites W2054848045 @default.
• W2014051729 cites W2055441692 @default.
• W2014051729 cites W2060364936 @default.
• W2014051729 cites W2060696024 @default.
• W2014051729 cites W2065637775 @default.
• W2014051729 cites W2074096799 @default.
• W2014051729 cites W2080275316 @default.
• W2014051729 cites W2080523215 @default.
• W2014051729 cites W2081098333 @default.
• W2014051729 cites W2081646940 @default.
• W2014051729 cites W2088082492 @default.
• W2014051729 cites W2090760765 @default.
• W2014051729 cites W2094092110 @default.
• W2014051729 cites W2099013228 @default.
• W2014051729 cites W2102849896 @default.
• W2014051729 cites W2104788426 @default.
• W2014051729 cites W2112253421 @default.
• W2014051729 cites W2114197097 @default.
• W2014051729 cites W2114265914 @default.
• W2014051729 cites W2122522583 @default.
• W2014051729 cites W2123453097 @default.
• W2014051729 cites W2127613892 @default.
• W2014051729 cites W2138777996 @default.
• W2014051729 cites W2140523553 @default.
• W2014051729 cites W2153383004 @default.
• W2014051729 cites W2156876163 @default.
• W2014051729 cites W2157271342 @default.
• W2014051729 cites W2160655220 @default.
• W2014051729 cites W2160697532 @default.
• W2014051729 cites W2165710145 @default.
• W2014051729 cites W2170444631 @default.
• W2014051729 cites W2171590436 @default.
• W2014051729 cites W2036895376 @default.
• W2014051729 doi "https://doi.org/10.1242/dev.100487" @default.
• W2014051729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4773893" @default.
• W2014051729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24449838" @default.

• next