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• W2014054401 endingPage "307" @default.
• W2014054401 startingPage "296" @default.
• W2014054401 abstract "IL-1β production is critically regulated by cytosolic molecular complexes, termed inflammasomes. Different inflammasome complexes have been described to date. While all inflammasomes recognize certain pathogens, it is the distinctive feature of NLRP3 inflammasome to be activated by many and diverse stimuli making NLRP3 the most versatile, and importantly also the most clinically implicated inflammasome. However, NLRP3 activation has remained the most enigmatic. It is not plausible that the intracellular NLRP3 receptor is able to detect all of its many and diverse triggers through direct interactions; instead, it is discussed that NLRP3 is responding to certain generic cellular stress-signals induced by the multitude of molecules that trigger its activation. An ever increasing number of studies link the sensing of cellular stress signals to a direct pathophysiological role of NLRP3 activation in a wide range of autoinflammatory and autoimmune disorders, and thus provide a novel mechanistic rational, on how molecules trigger and support sterile inflammatory diseases. A vast interest has created to unravel how NLRP3 becomes activated, since mechanistic insight is the prerequisite for a knowledge-based development of therapeutic intervention strategies that specifically target the NLRP3 triggered IL-1β production. In this review, we have updated knowledge on NLRP3 inflammasome assembly and activation and on the pyrin domain in NLRP3 that could represent a drug target to treat sterile inflammatory diseases. We have reported mutations in NLRP3 that were found to be associated with certain diseases. In addition, we have reviewed the functional link between NLRP3 inflammasome, the regulator of cellular redox status Trx/TXNIP complex, endoplasmic reticulum stress and the pathogenesis of diseases such as type 2 diabetes. Finally, we have provided data on NLRP3 inflammasome, as a critical regulator involved in the pathogenesis of obesity and cardiovascular diseases." @default.
• W2014054401 created "2016-06-24" @default.
• W2014054401 creator A5003681768 @default.
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• W2014054401 creator A5054905654 @default.
• W2014054401 creator A5065504581 @default.
• W2014054401 creator A5085957154 @default.
• W2014054401 date "2015-04-01" @default.
• W2014054401 modified "2023-10-17" @default.
• W2014054401 title "NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases" @default.
• W2014054401 cites W1523693806 @default.
• W2014054401 cites W1523979203 @default.
• W2014054401 cites W1529674879 @default.
• W2014054401 cites W1571910978 @default.
• W2014054401 cites W1573590923 @default.
• W2014054401 cites W1593760300 @default.
• W2014054401 cites W1594893804 @default.
• W2014054401 cites W1605844554 @default.
• W2014054401 cites W1767329992 @default.
• W2014054401 cites W1894792769 @default.
• W2014054401 cites W1942214720 @default.
• W2014054401 cites W1966318794 @default.
• W2014054401 cites W1967342482 @default.
• W2014054401 cites W1968305129 @default.
• W2014054401 cites W1970436087 @default.
• W2014054401 cites W1972483153 @default.
• W2014054401 cites W1973351162 @default.
• W2014054401 cites W1974744480 @default.
• W2014054401 cites W1978274182 @default.
• W2014054401 cites W1979132095 @default.
• W2014054401 cites W1981837371 @default.
• W2014054401 cites W1984629678 @default.
• W2014054401 cites W1985525204 @default.
• W2014054401 cites W1986049860 @default.
• W2014054401 cites W1987329700 @default.
• W2014054401 cites W1992014522 @default.
• W2014054401 cites W1992980231 @default.
• W2014054401 cites W1993714301 @default.
• W2014054401 cites W1993966022 @default.
• W2014054401 cites W1995126002 @default.
• W2014054401 cites W1995849206 @default.
• W2014054401 cites W1996264333 @default.
• W2014054401 cites W1996507370 @default.
• W2014054401 cites W1996830451 @default.
• W2014054401 cites W1996866382 @default.
• W2014054401 cites W1999276471 @default.
• W2014054401 cites W1999634145 @default.
• W2014054401 cites W2002393607 @default.
• W2014054401 cites W2002611667 @default.
• W2014054401 cites W2003362321 @default.
• W2014054401 cites W2004170579 @default.
• W2014054401 cites W2007450401 @default.
• W2014054401 cites W2009004909 @default.
• W2014054401 cites W2009435405 @default.
• W2014054401 cites W2009497505 @default.
• W2014054401 cites W2009771629 @default.
• W2014054401 cites W2009800174 @default.
• W2014054401 cites W2011297849 @default.
• W2014054401 cites W2013183032 @default.
• W2014054401 cites W2014602273 @default.
• W2014054401 cites W2015289974 @default.
• W2014054401 cites W2015449243 @default.
• W2014054401 cites W2016693012 @default.
• W2014054401 cites W2018220404 @default.
• W2014054401 cites W2018563185 @default.
• W2014054401 cites W2018607502 @default.
• W2014054401 cites W2018788678 @default.
• W2014054401 cites W2025355874 @default.
• W2014054401 cites W2025449580 @default.
• W2014054401 cites W2026020817 @default.
• W2014054401 cites W2026212701 @default.
• W2014054401 cites W2028342387 @default.
• W2014054401 cites W2028519649 @default.
• W2014054401 cites W2028545985 @default.
• W2014054401 cites W2032786707 @default.
• W2014054401 cites W2034029712 @default.
• W2014054401 cites W2034354758 @default.
• W2014054401 cites W2034940658 @default.
• W2014054401 cites W2034946303 @default.
• W2014054401 cites W2036467841 @default.
• W2014054401 cites W2036670100 @default.
• W2014054401 cites W2036811146 @default.
• W2014054401 cites W2039898262 @default.
• W2014054401 cites W2040551968 @default.
• W2014054401 cites W2044210137 @default.
• W2014054401 cites W2045561438 @default.
• W2014054401 cites W2045969462 @default.
• W2014054401 cites W2047423808 @default.
• W2014054401 cites W2048032544 @default.
• W2014054401 cites W2048211245 @default.
• W2014054401 cites W2048827030 @default.
• W2014054401 cites W2050449334 @default.
• W2014054401 cites W2050798656 @default.
• W2014054401 cites W2051303794 @default.
• W2014054401 cites W2052215470 @default.
• W2014054401 cites W2052617165 @default.

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