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- W2014057998 abstract "Differential diagnosis of primary and metastatic carcinomas of the liver can be problematic and may require immunohistochemical work-up. Recently, new immunohistochemical markers have been introduced with promising results in this area. We studied three of these markers, human hepatocyte antibody (HepPar-1), human epithelial-related antigen (MOC-31), and thyroid transcription factor-1 (TTF-1), in cell-block sections of fine-needle aspirations from 30 hepatocellular carcinomas and 27 metastatic carcinomas from various sites. Of 27 metastatic carcinomas, all but one were positive for MOC-31 and, all but one were negative for HepPar-1. TTF-1 was positive only in the nuclei of metastatic poorly differentiated neuroendocrine carcinoma from the lung. Of 30 hepatocellular carcinomas, 26 were positive for HepPar-1 and all were negative for MOC-31, while TTF-1 showed cytoplasmic staining in 23 cases. HepPar-1, MOC-31, and TTF-1 are complementary markers in the differential diagnosis of primary and metastatic carcinomas of the liver, with high sensitivity and specificity. Diagn. Cytopathol. 2005;33:166–172. © 2005 Wiley-Liss, Inc." @default.
- W2014057998 created "2016-06-24" @default.
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- W2014057998 date "2005-01-01" @default.
- W2014057998 modified "2023-10-18" @default.
- W2014057998 title "Recent immunohistochemical markers in the differential diagnosis of primary and metastatic carcinomas of the liver" @default.
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- W2014057998 doi "https://doi.org/10.1002/dc.20345" @default.
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