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- W2014061202 abstract "Pig liver mitochondria were found to catalyze 27-, 25- and 24-hydroxylation of cholesterol at relative rates of about 1:0.2:0.04. An apparently homogeneous preparation of pig liver mitochondrial cytochrome P-450-27 was found to catalyze the same three hydroxylations at about the same relative rates when reconstituted with adrenodoxin and adrenodoxin reductase. The 24-hydroxycholesterol formed was shown to consist of one of the two possible stereoisomers. When using specifically deuteriumlabeled substrates a significant isotope effect was observed in the case of 24-hydroxylation(KH/KD ⪢ 10), but not 25-hydroxylation (KH/KD = 1.1), or 27-hydroxylation (KH/KD = 1.1). The difference between the 24-hydroxylation and the other two hydroxylations may be due to different interactions between cholesterol and the same enzyme, with a resulting difference with respect to the rate-limiting step in the reaction. The physiological significance of the mitochondrial 24-hydroxylation is discussed." @default.
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- W2014061202 date "1993-02-01" @default.
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- W2014061202 title "24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver" @default.
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- W2014061202 doi "https://doi.org/10.1016/0005-2760(93)90094-p" @default.
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