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- W2014063079 abstract "BackgroundThere is growing concern that prenatal exposure to bisphenol A (BPA) and phthalates, which are widely used in consumer products, might affect susceptibility to infections and the development of allergy and asthma in children, but there are currently very few prospective studies.ObjectiveWe sought to evaluate whether prenatal exposure to BPA and phthalates increases the risk of respiratory and allergic outcomes in children at various ages from birth to 7 years.MethodsWe measured BPA and metabolites of high-molecular-weight phthalates, 4 di-(2-ethylhexyl) phthalate (DEHP) metabolites (Σ4DEHP) and mono-benzyl phthalate (MBzP), and 3 low-molecular-weight phthalate (LMWP) metabolites (Σ3LMWP) in urine samples collected during the first and third trimesters in pregnant women participating in the Infancia y Medio Ambiente–Sabadell birth cohort study. The occurrence of chest infections, bronchitis, wheeze, and eczema in children was assessed at ages 6 and 14 months and 4 and 7 years through questionnaires given to the mothers. Atopy (specific IgE measurement) and asthma (questionnaire) were assessed at ages 4 and 7 years, respectively.ResultsThe relative risks (RRs) of wheeze (RR, 1.20; 95% CI, 1.03-1.40; P = .02), chest infections (RR, 1.15; 95% CI, 1.00-1.32; P = .05), and bronchitis (RR, 1.18; 95% CI, 1.01-1.37; P = .04) at any age increased for each doubling in concentration of maternal urinary BPA. Σ4DEHP metabolites were associated with the same outcomes (wheeze: RR, 1.25; 95% CI, 1.04-1.50, P = .02; chest infections: RR, 1.15; 95% CI, 0.97-1.35; P = .11; bronchitis: RR, 1.20; 95% CI, 1.01-1.43; P = .04). MBzP was associated with higher risk of wheeze (RR, 1.15; 95% CI, 1.00-1.33; P = .05). The risk of asthma at age 7 years was also increased with increasing prenatal BPA, Σ4DEHP, and MBzP exposure. There were no other exposure-outcome associations.ConclusionsPrenatal exposure to BPA and high-molecular-weight phthalates might increase the risk of asthma symptoms and respiratory tract infections throughout childhood. There is growing concern that prenatal exposure to bisphenol A (BPA) and phthalates, which are widely used in consumer products, might affect susceptibility to infections and the development of allergy and asthma in children, but there are currently very few prospective studies. We sought to evaluate whether prenatal exposure to BPA and phthalates increases the risk of respiratory and allergic outcomes in children at various ages from birth to 7 years. We measured BPA and metabolites of high-molecular-weight phthalates, 4 di-(2-ethylhexyl) phthalate (DEHP) metabolites (Σ4DEHP) and mono-benzyl phthalate (MBzP), and 3 low-molecular-weight phthalate (LMWP) metabolites (Σ3LMWP) in urine samples collected during the first and third trimesters in pregnant women participating in the Infancia y Medio Ambiente–Sabadell birth cohort study. The occurrence of chest infections, bronchitis, wheeze, and eczema in children was assessed at ages 6 and 14 months and 4 and 7 years through questionnaires given to the mothers. Atopy (specific IgE measurement) and asthma (questionnaire) were assessed at ages 4 and 7 years, respectively. The relative risks (RRs) of wheeze (RR, 1.20; 95% CI, 1.03-1.40; P = .02), chest infections (RR, 1.15; 95% CI, 1.00-1.32; P = .05), and bronchitis (RR, 1.18; 95% CI, 1.01-1.37; P = .04) at any age increased for each doubling in concentration of maternal urinary BPA. Σ4DEHP metabolites were associated with the same outcomes (wheeze: RR, 1.25; 95% CI, 1.04-1.50, P = .02; chest infections: RR, 1.15; 95% CI, 0.97-1.35; P = .11; bronchitis: RR, 1.20; 95% CI, 1.01-1.43; P = .04). MBzP was associated with higher risk of wheeze (RR, 1.15; 95% CI, 1.00-1.33; P = .05). The risk of asthma at age 7 years was also increased with increasing prenatal BPA, Σ4DEHP, and MBzP exposure. There were no other exposure-outcome associations. Prenatal exposure to BPA and high-molecular-weight phthalates might increase the risk of asthma symptoms and respiratory tract infections throughout childhood." @default.
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- W2014063079 date "2015-02-01" @default.
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- W2014063079 title "Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy" @default.
- W2014063079 cites W1499211032 @default.
- W2014063079 cites W1588911223 @default.
- W2014063079 cites W1852065298 @default.
- W2014063079 cites W1966126737 @default.
- W2014063079 cites W1967983803 @default.
- W2014063079 cites W1970358298 @default.
- W2014063079 cites W1972860010 @default.
- W2014063079 cites W1974387205 @default.
- W2014063079 cites W1985779900 @default.
- W2014063079 cites W1988181654 @default.
- W2014063079 cites W1992889916 @default.
- W2014063079 cites W1995382033 @default.
- W2014063079 cites W1996583098 @default.
- W2014063079 cites W1998158718 @default.
- W2014063079 cites W2000096982 @default.
- W2014063079 cites W2008965066 @default.
- W2014063079 cites W2009758715 @default.
- W2014063079 cites W2010229648 @default.
- W2014063079 cites W2017848232 @default.
- W2014063079 cites W2033833869 @default.
- W2014063079 cites W2037740273 @default.
- W2014063079 cites W2037869318 @default.
- W2014063079 cites W2043780399 @default.
- W2014063079 cites W2050776663 @default.
- W2014063079 cites W2053370668 @default.
- W2014063079 cites W2053501212 @default.
- W2014063079 cites W2055900364 @default.
- W2014063079 cites W2056284251 @default.
- W2014063079 cites W2057941620 @default.
- W2014063079 cites W2061463820 @default.
- W2014063079 cites W2061569115 @default.
- W2014063079 cites W2061765430 @default.
- W2014063079 cites W2062347276 @default.
- W2014063079 cites W2063218936 @default.
- W2014063079 cites W2066683636 @default.
- W2014063079 cites W2075583374 @default.
- W2014063079 cites W2089034170 @default.
- W2014063079 cites W2089198100 @default.
- W2014063079 cites W2092051423 @default.
- W2014063079 cites W2093683842 @default.
- W2014063079 cites W2099371266 @default.
- W2014063079 cites W2100301770 @default.
- W2014063079 cites W2101860343 @default.
- W2014063079 cites W2104781990 @default.
- W2014063079 cites W2108165606 @default.
- W2014063079 cites W2117253916 @default.
- W2014063079 cites W2120570033 @default.
- W2014063079 cites W2125581814 @default.
- W2014063079 cites W2125591168 @default.
- W2014063079 cites W2134862220 @default.
- W2014063079 cites W2140364790 @default.
- W2014063079 cites W2142010704 @default.
- W2014063079 cites W2144020033 @default.
- W2014063079 cites W2144150352 @default.
- W2014063079 cites W2148750103 @default.
- W2014063079 cites W2149860264 @default.
- W2014063079 cites W2151444856 @default.
- W2014063079 cites W2153830480 @default.
- W2014063079 cites W2169084332 @default.
- W2014063079 cites W2331936027 @default.
- W2014063079 doi "https://doi.org/10.1016/j.jaci.2014.09.030" @default.
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