Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014063574> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2014063574 endingPage "161" @default.
- W2014063574 startingPage "153" @default.
- W2014063574 abstract "This study was conducted to characterise the pharmacokinetics of a liposomal pharmaceutical product of amphotericin B (LAB) in three neutropenic cancer patients complicated by suspected fungal infections. LAB was administered at a constant dose of 50 mg/day over 1--6 h by intravenous infusion, and blood samples were obtained between two infusion intervals without complicating the systemic therapy of the patients. Quantitative analysis of amphotericin B (AB) in plasma was established by a validated reversed-phase high-performance liquid chromatographic (HPLC) assay. Model independent pharmacokinetic parameters were estimated using area and moment analysis. Administration of LAB to the first patient (day 1) diagnosed as malignant melanoma resulted in a mean maximum concentration (C(max)) of 679+/-6 ng/ml and a mean minimum concentration (C(min)) of 139+/-9 ng/ml of AB. Pre-dose, C(max) and C(min) values of AB, after multiple LAB dosing to the other two patients both having acute myeloblastic leukemia were found to be 440+/-6, 1140+/-10, 409+/-11 ng/ml (day 19) and 408+/-3, 1180+/-10, and 283+/-1 ng/ml (day 9), respectively. The area under the plasma concentration-time curve (AUC) and the mean residence time (MRT) calculated between the two infusion intervals were 6180 ngh/ml, 7.79 h (day 1) for the first patient; 13,700 ng.h/ml, 10.5 h (day 19) and 14,000 ng.h/ml, 9.93 h (day 9) for the other two patients, respectively. The pharmacokinetic profiles and non-compartmental parameters calculated were comparable for both patients diagnosed with acute myeloblastic leukemia after multiple dosing at steady state, which also demonstrated a twofold increase in their AUC values compared with the AUC of the first patient. Although C(min) values supported the assumption that there was AB accumulation in plasma and this accumulation could be increased at high doses, LAB was administered safely to these patients and well tolerated at the doses given." @default.
- W2014063574 created "2016-06-24" @default.
- W2014063574 creator A5001003746 @default.
- W2014063574 creator A5021124088 @default.
- W2014063574 creator A5029610866 @default.
- W2014063574 creator A5038545776 @default.
- W2014063574 creator A5054863331 @default.
- W2014063574 date "2001-02-01" @default.
- W2014063574 modified "2023-09-27" @default.
- W2014063574 title "Pharmacokinetics of liposomal amphotericin B in neutropenic cancer patients" @default.
- W2014063574 cites W1598924609 @default.
- W2014063574 cites W1978263354 @default.
- W2014063574 cites W1994998334 @default.
- W2014063574 cites W1999151652 @default.
- W2014063574 cites W2005579088 @default.
- W2014063574 cites W2005581514 @default.
- W2014063574 cites W2012504003 @default.
- W2014063574 cites W2014098784 @default.
- W2014063574 cites W2024944590 @default.
- W2014063574 cites W2037064781 @default.
- W2014063574 cites W2053303703 @default.
- W2014063574 cites W2058328127 @default.
- W2014063574 cites W2084068955 @default.
- W2014063574 cites W2088739831 @default.
- W2014063574 cites W2098753270 @default.
- W2014063574 cites W2109718032 @default.
- W2014063574 cites W2114983682 @default.
- W2014063574 cites W2119390272 @default.
- W2014063574 cites W2120307846 @default.
- W2014063574 cites W2121381809 @default.
- W2014063574 cites W2140212092 @default.
- W2014063574 cites W2141025633 @default.
- W2014063574 cites W2148055298 @default.
- W2014063574 cites W2162801555 @default.
- W2014063574 cites W2162912313 @default.
- W2014063574 cites W2165692316 @default.
- W2014063574 cites W2326799365 @default.
- W2014063574 cites W2402051390 @default.
- W2014063574 cites W2411812256 @default.
- W2014063574 cites W344116166 @default.
- W2014063574 doi "https://doi.org/10.1016/s0378-5173(00)00663-3" @default.
- W2014063574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11165103" @default.
- W2014063574 hasPublicationYear "2001" @default.
- W2014063574 type Work @default.
- W2014063574 sameAs 2014063574 @default.
- W2014063574 citedByCount "12" @default.
- W2014063574 countsByYear W20140635742019 @default.
- W2014063574 countsByYear W20140635742020 @default.
- W2014063574 countsByYear W20140635742022 @default.
- W2014063574 crossrefType "journal-article" @default.
- W2014063574 hasAuthorship W2014063574A5001003746 @default.
- W2014063574 hasAuthorship W2014063574A5021124088 @default.
- W2014063574 hasAuthorship W2014063574A5029610866 @default.
- W2014063574 hasAuthorship W2014063574A5038545776 @default.
- W2014063574 hasAuthorship W2014063574A5054863331 @default.
- W2014063574 hasConcept C112705442 @default.
- W2014063574 hasConcept C16005928 @default.
- W2014063574 hasConcept C179998833 @default.
- W2014063574 hasConcept C185592680 @default.
- W2014063574 hasConcept C2779548794 @default.
- W2014063574 hasConcept C2779629538 @default.
- W2014063574 hasConcept C43617362 @default.
- W2014063574 hasConcept C71924100 @default.
- W2014063574 hasConcept C76318530 @default.
- W2014063574 hasConcept C98274493 @default.
- W2014063574 hasConceptScore W2014063574C112705442 @default.
- W2014063574 hasConceptScore W2014063574C16005928 @default.
- W2014063574 hasConceptScore W2014063574C179998833 @default.
- W2014063574 hasConceptScore W2014063574C185592680 @default.
- W2014063574 hasConceptScore W2014063574C2779548794 @default.
- W2014063574 hasConceptScore W2014063574C2779629538 @default.
- W2014063574 hasConceptScore W2014063574C43617362 @default.
- W2014063574 hasConceptScore W2014063574C71924100 @default.
- W2014063574 hasConceptScore W2014063574C76318530 @default.
- W2014063574 hasConceptScore W2014063574C98274493 @default.
- W2014063574 hasIssue "1-2" @default.
- W2014063574 hasLocation W20140635741 @default.
- W2014063574 hasLocation W20140635742 @default.
- W2014063574 hasOpenAccess W2014063574 @default.
- W2014063574 hasPrimaryLocation W20140635741 @default.
- W2014063574 hasRelatedWork W1990332719 @default.
- W2014063574 hasRelatedWork W2089190078 @default.
- W2014063574 hasRelatedWork W2090017399 @default.
- W2014063574 hasRelatedWork W2091530730 @default.
- W2014063574 hasRelatedWork W2093917715 @default.
- W2014063574 hasRelatedWork W2129639901 @default.
- W2014063574 hasRelatedWork W2328651485 @default.
- W2014063574 hasRelatedWork W2382960470 @default.
- W2014063574 hasRelatedWork W2412066373 @default.
- W2014063574 hasRelatedWork W3042350762 @default.
- W2014063574 hasVolume "213" @default.
- W2014063574 isParatext "false" @default.
- W2014063574 isRetracted "false" @default.
- W2014063574 magId "2014063574" @default.
- W2014063574 workType "article" @default.