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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014064334> ?p ?o ?g. }

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• W2014064334 abstract "(-)-6-[2-[4-(3-Fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone was identified as an orally active NR2B-subunit selective N-methyl-d-aspartate (NMDA) receptor antagonist. It has very high selectivity for NR2B subunits containing NMDA receptors versus the HERG-channel inhibition (therapeutic index=4200 vs NR2B binding IC(50)). This compound has improved pharmacokinetic properties compared to the prototype CP-101,606." @default.
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• W2014064334 date "2007-10-01" @default.
• W2014064334 modified "2023-10-04" @default.
• W2014064334 title "Discovery of (−)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone—A potent NR2B-selective N-methyl d-aspartate (NMDA) antagonist for the treatment of pain" @default.
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• W2014064334 doi "https://doi.org/10.1016/j.bmcl.2007.08.014" @default.
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