FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014066635> ?p ?o ?g. }

• W2014066635 endingPage "48" @default.
• W2014066635 startingPage "39" @default.
• W2014066635 abstract "Many biodegradable polymers have been developed for controlled drug delivery. The plethora of drug therapies and types of drugs demand different formulations, fabrications conditions and release kinetics. No one single polymer can satisfy all the requirements. To extend the properties of poly(D,L-lactide) (PLA), we synthesized copolymers of PLA and poly(ethylethylene phosphate) (PEEP) by ring-opening polymerization using Al(Oipr)3 as the initiator. The copolymers were structurally characterized by IR and 1H NMR. DSC data confirmed the formation of random microphase structure in all the copolymers, and showed a decrease of Tg from 43.2 to -22.6 degrees C when the molar content of ethylethylene phosphate (EEP) increased from 5 to 40%. The hydrophilicity of the copolymers increased with EEP content. In contrast to the degradation behavior of PLA, disc samples made of PLAEEP90 showed a linear weight loss profile in PBS (pH 7.4) at 37 degrees C. BSA microspheres using PLAEEP90 were prepared by double-emulsion method, yielding a loading level of 4.3% and a loading efficiency of 75%. The BSA release profile consisted of an initial burst (9%) on the first day, followed by a daily 4% release for the following 40 days, resulting in 91% of the BSA release in a near linear manner. The released BSA remained intact according to SDS-PAGE data. Cytotoxicity and histopathology studies showed low toxicity in HeLa cells and good tissue biocompatibility in mouse brain, respectively. PLAEEP is a promising biodegradable polymer for controlled drug delivery." @default.
• W2014066635 created "2016-06-24" @default.
• W2014066635 creator A5008147959 @default.
• W2014066635 creator A5050822671 @default.
• W2014066635 creator A5089213497 @default.
• W2014066635 date "2003-09-01" @default.
• W2014066635 modified "2023-10-10" @default.
• W2014066635 title "Poly(d,llactide–co-ethyl ethylene phosphate)s as new drug carriers" @default.
• W2014066635 cites W1968783847 @default.
• W2014066635 cites W1974828397 @default.
• W2014066635 cites W1985555415 @default.
• W2014066635 cites W1998940147 @default.
• W2014066635 cites W2000200774 @default.
• W2014066635 cites W2023678209 @default.
• W2014066635 cites W2027200679 @default.
• W2014066635 cites W2047796161 @default.
• W2014066635 cites W2049191131 @default.
• W2014066635 cites W2062135876 @default.
• W2014066635 cites W2063024662 @default.
• W2014066635 cites W2066190409 @default.
• W2014066635 cites W2089755449 @default.
• W2014066635 cites W2123245462 @default.
• W2014066635 cites W2136369523 @default.
• W2014066635 cites W2142264194 @default.
• W2014066635 cites W2333038355 @default.
• W2014066635 cites W283469004 @default.
• W2014066635 cites W4211147424 @default.
• W2014066635 doi "https://doi.org/10.1016/s0168-3659(03)00294-3" @default.
• W2014066635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14499184" @default.
• W2014066635 hasPublicationYear "2003" @default.
• W2014066635 type Work @default.
• W2014066635 sameAs 2014066635 @default.
• W2014066635 citedByCount "85" @default.
• W2014066635 countsByYear W20140666352012 @default.
• W2014066635 countsByYear W20140666352013 @default.
• W2014066635 countsByYear W20140666352014 @default.
• W2014066635 countsByYear W20140666352015 @default.
• W2014066635 countsByYear W20140666352016 @default.
• W2014066635 countsByYear W20140666352017 @default.
• W2014066635 countsByYear W20140666352018 @default.
• W2014066635 countsByYear W20140666352019 @default.
• W2014066635 countsByYear W20140666352020 @default.
• W2014066635 countsByYear W20140666352021 @default.
• W2014066635 countsByYear W20140666352022 @default.
• W2014066635 countsByYear W20140666352023 @default.
• W2014066635 crossrefType "journal-article" @default.
• W2014066635 hasAuthorship W2014066635A5008147959 @default.
• W2014066635 hasAuthorship W2014066635A5050822671 @default.
• W2014066635 hasAuthorship W2014066635A5089213497 @default.
• W2014066635 hasConcept C121332964 @default.
• W2014066635 hasConcept C13245373 @default.
• W2014066635 hasConcept C13965031 @default.
• W2014066635 hasConcept C148898269 @default.
• W2014066635 hasConcept C1491633281 @default.
• W2014066635 hasConcept C15920480 @default.
• W2014066635 hasConcept C178790620 @default.
• W2014066635 hasConcept C185592680 @default.
• W2014066635 hasConcept C188027245 @default.
• W2014066635 hasConcept C203897987 @default.
• W2014066635 hasConcept C2776743539 @default.
• W2014066635 hasConcept C2777132085 @default.
• W2014066635 hasConcept C2777230088 @default.
• W2014066635 hasConcept C2777366897 @default.
• W2014066635 hasConcept C2777516009 @default.
• W2014066635 hasConcept C2778123984 @default.
• W2014066635 hasConcept C2779820397 @default.
• W2014066635 hasConcept C44228677 @default.
• W2014066635 hasConcept C45211672 @default.
• W2014066635 hasConcept C521977710 @default.
• W2014066635 hasConcept C55493867 @default.
• W2014066635 hasConcept C62520636 @default.
• W2014066635 hasConceptScore W2014066635C121332964 @default.
• W2014066635 hasConceptScore W2014066635C13245373 @default.
• W2014066635 hasConceptScore W2014066635C13965031 @default.
• W2014066635 hasConceptScore W2014066635C148898269 @default.
• W2014066635 hasConceptScore W2014066635C1491633281 @default.
• W2014066635 hasConceptScore W2014066635C15920480 @default.
• W2014066635 hasConceptScore W2014066635C178790620 @default.
• W2014066635 hasConceptScore W2014066635C185592680 @default.
• W2014066635 hasConceptScore W2014066635C188027245 @default.
• W2014066635 hasConceptScore W2014066635C203897987 @default.
• W2014066635 hasConceptScore W2014066635C2776743539 @default.
• W2014066635 hasConceptScore W2014066635C2777132085 @default.
• W2014066635 hasConceptScore W2014066635C2777230088 @default.
• W2014066635 hasConceptScore W2014066635C2777366897 @default.
• W2014066635 hasConceptScore W2014066635C2777516009 @default.
• W2014066635 hasConceptScore W2014066635C2778123984 @default.
• W2014066635 hasConceptScore W2014066635C2779820397 @default.
• W2014066635 hasConceptScore W2014066635C44228677 @default.
• W2014066635 hasConceptScore W2014066635C45211672 @default.
• W2014066635 hasConceptScore W2014066635C521977710 @default.
• W2014066635 hasConceptScore W2014066635C55493867 @default.
• W2014066635 hasConceptScore W2014066635C62520636 @default.
• W2014066635 hasIssue "1-2" @default.
• W2014066635 hasLocation W20140666351 @default.
• W2014066635 hasLocation W20140666352 @default.
• W2014066635 hasOpenAccess W2014066635 @default.
• W2014066635 hasPrimaryLocation W20140666351 @default.

• next