FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014067369> ?p ?o ?g. }

• W2014067369 endingPage "81" @default.
• W2014067369 startingPage "74" @default.
• W2014067369 abstract "Interferon-gamma-inducible 10 kd protein (IP-10) is an ELR (Glu-Leu-Arg)(-) alpha chemokine with known chemotactic effects on T cells and monocytes, as well as anti-viral, anti-angiogenic, and anti-tumor effects. Previous studies have demonstrated that in cultured rat astrocytes and microglia, stimulation with LPS or virus can induce the expression of IP-10. In this study, we determined the pattern of IP-10 gene induction in primary human microglia and astrocytes by cytokines and LPS using ribonuclease protection assay. The expression of IP-10 mRNA was compared with that of other alpha (IL-8) and beta chemokines. The results showed that in human microglia, IP-10 expression was induced equally potently by LPS, IFNbeta or IFNgamma. Proinflammatory cytokines IL-1beta or TNFalpha also induced small amounts of IP-10 mRNA. Anti-inflammatory cytokines IL-4, IL-10 and TGFbeta were ineffective in inducing IP-10 in microglia. In human astrocytes, induction of IP-10 mRNA by cytokines was similar to that in microglia. LPS, however, was ineffective in inducing IP-10 in human astrocytes. The monocyte chemoattractant beta-chemokine I-309 mRNA was induced in human astrocytes and microglia by IFNbeta or IFNgamma, or by LPS in microglia, showing a tight co-regulation with IP-10 mRNA expression. In contrast to the potent induction of IP-10 and I-309 by IFNs in human glia, the ELR(+) alpha chemokine IL-8 mRNA was induced by IL-1beta and TNFalpha, and to a lesser extent by IFNbeta in microglia. IFNbeta but not IFNgamma was effective in inducing the expression of beta chemokines MIP-1alpha and MIP-1beta in human microglia, with the levels of mRNA similar to those induced by IL-1beta or TNFalpha. Neither MIP-1alpha nor MIP-1beta mRNAs were induced by any stimulation in human astrocytes. The induction of RANTES mRNA in microglia by IFNbeta, IL-1beta or TNFalpha was variable, showing no to low level expression depending on the case, whereas LPS provided a consistent inducing signal. In astrocytes, only cytokine combinations (IFN + IL-1beta) effectively induced the RANTES mRNA. These results demonstrate that distinct sets of chemokine genes are induced in human glial cells by cytokines and interferons. These results may have wide implications for inflammatory, vascular and neoplastic diseases of the CNS." @default.
• W2014067369 created "2016-06-24" @default.
• W2014067369 creator A5028958887 @default.
• W2014067369 creator A5057241613 @default.
• W2014067369 date "2000-03-01" @default.
• W2014067369 modified "2023-09-24" @default.
• W2014067369 title "Distinct patterns of stimulus-inducible chemokine mRNA accumulation in human fetal astrocytes and microglia" @default.
• W2014067369 cites W1485498049 @default.
• W2014067369 cites W1488696767 @default.
• W2014067369 cites W1495031513 @default.
• W2014067369 cites W1541718087 @default.
• W2014067369 cites W1582132479 @default.
• W2014067369 cites W1608043318 @default.
• W2014067369 cites W1611435732 @default.
• W2014067369 cites W1652237838 @default.
• W2014067369 cites W1784761870 @default.
• W2014067369 cites W1901938190 @default.
• W2014067369 cites W1948306789 @default.
• W2014067369 cites W1963855922 @default.
• W2014067369 cites W1992442767 @default.
• W2014067369 cites W1996183144 @default.
• W2014067369 cites W2001322346 @default.
• W2014067369 cites W2005659566 @default.
• W2014067369 cites W2021278130 @default.
• W2014067369 cites W2026638938 @default.
• W2014067369 cites W2028325426 @default.
• W2014067369 cites W2029565492 @default.
• W2014067369 cites W2033204154 @default.
• W2014067369 cites W2035134338 @default.
• W2014067369 cites W2045281561 @default.
• W2014067369 cites W2059614508 @default.
• W2014067369 cites W2065111916 @default.
• W2014067369 cites W2072173215 @default.
• W2014067369 cites W2073639128 @default.
• W2014067369 cites W2075838162 @default.
• W2014067369 cites W2086196933 @default.
• W2014067369 cites W2091720736 @default.
• W2014067369 cites W2119370734 @default.
• W2014067369 cites W2122946630 @default.
• W2014067369 cites W2125759758 @default.
• W2014067369 cites W2126360069 @default.
• W2014067369 cites W2129316387 @default.
• W2014067369 cites W2144414931 @default.
• W2014067369 cites W2155691564 @default.
• W2014067369 cites W2156411751 @default.
• W2014067369 cites W2166833329 @default.
• W2014067369 cites W2315090522 @default.
• W2014067369 cites W4211264883 @default.
• W2014067369 cites W4313331137 @default.
• W2014067369 cites W4313333659 @default.
• W2014067369 cites W4313333733 @default.
• W2014067369 cites W8802634 @default.
• W2014067369 doi "https://doi.org/10.1002/(sici)1098-1136(200003)30:1<74::aid-glia8>3.0.co;2-c" @default.
• W2014067369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10696146" @default.
• W2014067369 hasPublicationYear "2000" @default.
• W2014067369 type Work @default.
• W2014067369 sameAs 2014067369 @default.
• W2014067369 citedByCount "100" @default.
• W2014067369 countsByYear W20140673692012 @default.
• W2014067369 countsByYear W20140673692013 @default.
• W2014067369 countsByYear W20140673692014 @default.
• W2014067369 countsByYear W20140673692015 @default.
• W2014067369 countsByYear W20140673692017 @default.
• W2014067369 countsByYear W20140673692019 @default.
• W2014067369 countsByYear W20140673692020 @default.
• W2014067369 countsByYear W20140673692021 @default.
• W2014067369 countsByYear W20140673692022 @default.
• W2014067369 countsByYear W20140673692023 @default.
• W2014067369 crossrefType "journal-article" @default.
• W2014067369 hasAuthorship W2014067369A5028958887 @default.
• W2014067369 hasAuthorship W2014067369A5057241613 @default.
• W2014067369 hasConcept C101666144 @default.
• W2014067369 hasConcept C110015553 @default.
• W2014067369 hasConcept C13373296 @default.
• W2014067369 hasConcept C134018914 @default.
• W2014067369 hasConcept C153911025 @default.
• W2014067369 hasConcept C164027704 @default.
• W2014067369 hasConcept C170217031 @default.
• W2014067369 hasConcept C17991360 @default.
• W2014067369 hasConcept C203014093 @default.
• W2014067369 hasConcept C2776914184 @default.
• W2014067369 hasConcept C2777542381 @default.
• W2014067369 hasConcept C2779830541 @default.
• W2014067369 hasConcept C2780884517 @default.
• W2014067369 hasConcept C529278444 @default.
• W2014067369 hasConcept C86803240 @default.
• W2014067369 hasConcept C95444343 @default.
• W2014067369 hasConceptScore W2014067369C101666144 @default.
• W2014067369 hasConceptScore W2014067369C110015553 @default.
• W2014067369 hasConceptScore W2014067369C13373296 @default.
• W2014067369 hasConceptScore W2014067369C134018914 @default.
• W2014067369 hasConceptScore W2014067369C153911025 @default.
• W2014067369 hasConceptScore W2014067369C164027704 @default.
• W2014067369 hasConceptScore W2014067369C170217031 @default.
• W2014067369 hasConceptScore W2014067369C17991360 @default.
• W2014067369 hasConceptScore W2014067369C203014093 @default.
• W2014067369 hasConceptScore W2014067369C2776914184 @default.
• W2014067369 hasConceptScore W2014067369C2777542381 @default.

• next