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• W2014069105 abstract "New drug development strategies are needed to combat antimicrobial resistance. The object of this perspective is to highlight one such strategy: treating infections with sets of drugs rather than individual drugs. We will highlight three categories of combination therapy: those that inhibit targets in different pathways; those that inhibit distinct nodes in the same pathway; and those that inhibit the very same target in different ways. We will then consider examples of naturally occurring combination therapies produced by micro-organisms, and conclude by discussing key opportunities and challenges for making more widespread use of drug combinations." @default.
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• W2014069105 date "2011-10-01" @default.
• W2014069105 modified "2023-10-14" @default.
• W2014069105 title "Combination therapies for combating antimicrobial resistance" @default.
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• W2014069105 doi "https://doi.org/10.1016/j.mib.2011.08.003" @default.
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